Single 3-minute freeze for second-generation cryoballoon ablation: One-year follow-up after pulmonary vein isolation

Giuseppe Ciconte, Carlo De Asmundis, Juan Sieira, Giulio Conte, Giacomo Di Giovanni, Giacomo Mugnai, Yukio Saitoh, Giannis Baltogiannis, Ghazala Irfan, Hugo Enrique Coutiño-Moreno, Burak Hunuk, Vedran Velagić, Pedro Brugada, Gian Battista Chierchia

Research output: Contribution to journalArticlepeer-review


Background The second-generation cryoballoon (CB-Adv) is effective in achieving pulmonary vein isolation (PVI) with encouraging results. The mid-term clinical efficacy of a single 3-minute freeze, without a routine bonus application, has been recently demonstrated. Objective The purpose of this study was to assess long-term clinical outcome after PVI with the CB-Adv using a single 3-minute application. Methods A total of 143 consecutive patients (93 male [65%], mean age 59.6 ± 12.0 years) with paroxysmal atrial fibrillation (PAF; 113/143 [79%]) or early persistent atrial fibrillation (AF; 30/143 [21%]) underwent PVI using CB-Adv with a single 3-minute freeze. Atrial tachyarrhythmia recurrences were defined as symptomatic or documented episodes >30 seconds. Results After a single freeze, isolation could be reached in 94.1% of all identified pulmonary veins. Complete PVI was successfully achieved with 1.1 ± 0.4 mean freezes. Persistent phrenic nerve palsy occurred in 5 of 143 patients (3.5%). At a mean 12.1 ± 4.4 months of follow-up, after a 3-month blanking period (BP), 80.4% (115/143) were in stable sinus rhythm (93/113 [82.3%] for PAF; 22/30 [73.3%] for early persistent AF). Fifteen patients underwent a second procedure with radiofrequency ablation showing reconnection in 7 of 15 right-sided (46.7%) and 6 of 15 left-sided (40%) pulmonary veins. Relapses during BP (P

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalHeart Rhythm
Issue number4
Publication statusPublished - Apr 1 2015


  • 1-yearfollow-up
  • 3-minute freeze
  • Atrial fibrillation
  • Cryoballoon ablation
  • Pulmonaryveinisolation
  • Second-generationcryoballoon
  • Singlefreeze

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

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