TY - JOUR
T1 - Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model
AU - Cirioni, O.
AU - Giacometti, A.
AU - Ghiselli, R.
AU - Mocchegiani, F.
AU - Fineo, A.
AU - Orlando, F.
AU - Del Prete, M. S.
AU - Rocchi, M.
AU - Saba, V.
AU - Scalise, G.
PY - 2002
Y1 - 2002
N2 - The therapeutic etticacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. Rats were given an intraperitoneal injection of 2 × 1010 CFU of Escherichia coli and randomized to receive intraperitoneally isotonic sodium chloride solution, 60 mg of piperacillin per kg of body weight, and 1 mg of each magainin per kg alone and combined with 60 mg of piperacillin per kg. The main outcome measures were bacterial growth in abdominal exudate and plasma, endotoxin and tumor necrosis factor alpha (TNF-α) concentrations in plasma, and lethality. Treatments with the magainins achieved significant reductions of bacterial growth and plasma endotoxin and TNF-α concentrations. In general, treatments with the combinations of magainins and piperaciilin demonstrated the highest efficacies.
AB - The therapeutic etticacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. Rats were given an intraperitoneal injection of 2 × 1010 CFU of Escherichia coli and randomized to receive intraperitoneally isotonic sodium chloride solution, 60 mg of piperacillin per kg of body weight, and 1 mg of each magainin per kg alone and combined with 60 mg of piperacillin per kg. The main outcome measures were bacterial growth in abdominal exudate and plasma, endotoxin and tumor necrosis factor alpha (TNF-α) concentrations in plasma, and lethality. Treatments with the magainins achieved significant reductions of bacterial growth and plasma endotoxin and TNF-α concentrations. In general, treatments with the combinations of magainins and piperaciilin demonstrated the highest efficacies.
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U2 - 10.1128/AAC.46.1.101-104.2002
DO - 10.1128/AAC.46.1.101-104.2002
M3 - Article
C2 - 11751118
AN - SCOPUS:0036136727
VL - 46
SP - 101
EP - 104
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -