Abstract
The pharmacokinetics of primidone (PRM) after oral administration of a single 500 mg dose was studied in 7 patients with acute viral hepatitis and 7 healthy control subjects. The elimination half-life and the apparent clearance of unchanged PRM in the patients were 18.0±3.1 h and 42±14 ml·h-1·kg-1, respectively (mean ± SD) and did not differ significantly from the values in the controls (half-life 17.0±2.4 h; clearance 35±8 ml·h-1·kg-1). The metabolite phenylethylmalonamide (PEMA) was detected in the serum of all normal subjects within 2-24 h. By contrast, serum levels of this metabolite were undetectable (
Original language | English |
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Pages (from-to) | 465-469 |
Number of pages | 5 |
Journal | European Journal of Clinical Pharmacology |
Volume | 27 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 1984 |
Keywords
- primidone
- primidone metabolism
- single-dose kinetics
- viral hepatitis
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)