Single-dose netilmicin therapy of complicated and uncomplicated lower urinary tract infections in children

A. Vigano, A. Dalla Villa, C. Bianchi, G. Gandini, F. Gaboardi, N. Principi

Research output: Contribution to journalArticle

Abstract

Thirty children (age 3 months to 10 years) with complicated and uncomplicated lower urinary tract infections were treated with a single intramuscular injection of netilmicin 4.5 mg/kg. The diagnosis of lower urinary tract infection was based on the absence of fever and the presence of normal values for erythrocyte sedimentation rate, C-reactive protein concentration and urinary excretion of N-acetyl-β-D-glucosaminidase. Follow-up urine cultures in all children demonstrated a cure rate of 97% and reinfection and relapse rates each of 7% respectively. The subgroup (12 children) with radiological abnormalities of urinary tract showed a cure rate of 92%, and reinfection and relapse rates of 9% respectively. The rates of cure, reinfection and relapse in the complicated and uncomplicated urinary tract infections were not statistically different (p>0.05). A pharmacokinetic study (performed in 5 children) demonstrated that netilmicin urinary concentrations were over the MIC's of the infecting organisms up to 96 hours after the single-dose injection. Netilmicin was well tolerated and no side effects appeared during treatment. Single-dose netilmicin therapy is an effective and safe regimen for complicated and uncomplicated urinary tract infections in children. The response to single-dose netilmicin therapy seems to be related to its prolonged urinary elimination.

Original languageEnglish
Pages (from-to)584-588
Number of pages5
JournalActa Paediatrica Scandinavica
Volume74
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Vigano, A., Dalla Villa, A., Bianchi, C., Gandini, G., Gaboardi, F., & Principi, N. (1985). Single-dose netilmicin therapy of complicated and uncomplicated lower urinary tract infections in children. Acta Paediatrica Scandinavica, 74(4), 584-588.