The pharmacokinetics of a single oral dose of carbamazepine-10,11-epoxide (CBZ-E, 100 mg) were compared in 10 patients on chronic monotherapy with lamotrigine (LTG, 200-300 mg/day) and in 10 drug-free healthy control subjects. CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7.2 ± 1.6 vs 6.1 ± 0.9 h; apparent oral clearance: 110.8 ± 53.1 vs 120.5 ± 29.9 ml/h/kg; apparent volume of distribution: 1.08 ± 0.37 vs 1.04 ± 0.25 l/kg respectively; means ± s.d.). These data indicate that, contrary to previous suggestions, LTG has no effect on the metabolic disposition of CBZ-E.
- Drug interaction
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health