Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy

F. Pisania, B. Xiao, A. Fazio, E. Spina, E. Perucca, T. Tomson

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics of a single oral dose of carbamazepine-10,11-epoxide (CBZ-E, 100 mg) were compared in 10 patients on chronic monotherapy with lamotrigine (LTG, 200-300 mg/day) and in 10 drug-free healthy control subjects. CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7.2 ± 1.6 vs 6.1 ± 0.9 h; apparent oral clearance: 110.8 ± 53.1 vs 120.5 ± 29.9 ml/h/kg; apparent volume of distribution: 1.08 ± 0.37 vs 1.04 ± 0.25 l/kg respectively; means ± s.d.). These data indicate that, contrary to previous suggestions, LTG has no effect on the metabolic disposition of CBZ-E.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalEpilepsy Research
Volume19
Issue number3
DOIs
Publication statusPublished - 1994

Keywords

  • Carbamazepine-10,11-epoxide
  • Drug interaction
  • Lamotrigine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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