Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome

G. Basilisco, M. G. Camboni, A. Bozzani, M. Molgora, P. A. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

The lactulose hydrogen breath test was used to assess the effect of a single dose of the β2-adrenoceptor agonist ritodrine on orocaecal transit time in 11 patients (three men) with irritable bowel syndrome. Transit time (median values, range) was significantly longer (P <0.01) after ritodrine than after placebo (120, 50-200 vs 75, 40-100 min). Median heart rate was similar before treatments whereas the maximal increase in heart rate was significantly greater (P <0.01) after ritodrine than after placebo.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume29
Issue number3
Publication statusPublished - 1990

Keywords

  • β-adrenoceptor agonist
  • breath tests
  • gastrointestinal motility
  • irritable bowel syndrome

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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