Single-epoch analysis of interleaved evoked potentials and fMRI responses during steady-state visual stimulation

M. Bianciardi, L. Bianchi, G. Garreffa, M. Abbafati, F. Di Russo, M. G. Marciani, E. Macaluso

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Aim of the study was to record BOLD-fMRI interleaved with evoked potentials for single-epochs of visual stimulation and to investigate the possible relationship between these two measures. Methods: Sparse recording of fMRI and EEG allowed us to measure BOLD responses and evoked potentials on an epoch-by-epoch basis. To obtain robust estimates of evoked potentials, we used blocks of contrast-reversing visual stimuli eliciting steady-state visual evoked potentials (SSVEPs). For each block we acquired one volume of fMRI data and we then tested for co-variations between SSVEPs and fMRI signals. Our analyses tested for frequency-specific co-variation between the two measurements that could not be explained by the mere presence/absence of the visual stimulation. Results: Condition-specific single-epoch SSVEPs and fMRI responses were observed at occipital sites. Combined SSVEPs-fMRI analysis at the single-epoch level did not reveal any significant correlation between the two recordings. However, both signals contained stimulation-specific linear decreases that may relate to neuronal habituation. Conclusions: Our findings demonstrate robust estimation of single-epoch evoked potentials and fMRI responses during interleaved recording, using visual steady-state stimulation. Significance: Single-epochs analysis of evoked potentials and fMRI signals is feasible for interleaved SSVEPs-fMRI recordings.

Original languageEnglish
Pages (from-to)738-747
Number of pages10
JournalClinical Neurophysiology
Volume120
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • BOLD-fMRI
  • Correlation analysis
  • Multi-modal imaging
  • Single-epoch
  • Steady-state evoked potentials
  • Visual stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Fingerprint

Dive into the research topics of 'Single-epoch analysis of interleaved evoked potentials and fMRI responses during steady-state visual stimulation'. Together they form a unique fingerprint.

Cite this