Single-joint rapid arm movements in normal subjects and in patients with motor disorders

A. Berardelli, M. Hallett, J. C. Rothwell, R. Agostino, M. Manfredi, P. D. Thompson, C. D. Marsden

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

In normal subjects the execution of single rapid one-joint movements is characterized by an electromyographic (EMG) pattern composed of three discrete bursts of activity: two bursts (first and second agonist bursts, or AG1 and AG2) are present in the agonist muscle separated by an almost complete period of electrical silence. During this pause, another burst (antagonist burst, or ANT) occurs in the antagonist muscle. If a rapid movement is executed during tonic activation of the agonist muscle, tonic activity is inhibited just prior to AG1 onset (agonist inhibition). Similarly, if the movement is performed during tonic activation of the antagonist muscle, such activity is also inhibited prior to AG1 onset (antagonist inhibition). Antagonist inhibition also starts prior to AG1 onset and lasts until ANT onset. A general descriptor of the kinematic features related to the EMG pattern described above is a symmetrical and unimodal velocity profile that is bell-shaped and shows an acceleration time roughly equal to the deceleration time. This holds true for movements performed under low accuracy constraints; as accuracy demands become stricter and stricter the peak velocity decreases but, as long as the movement is made with one continuous trajectory, the velocity profile remains roughly symmetrical. In general terms, the function of AG1 is to provide the impulsive force to start the movement; the function of ANT is to halt the movement at the desired end-point; and the function of AG2 is to dampen out the oscillations which might occur at the end of the movement. The timing and size of the bursts vary according to the speed and amplitude of the movement. The origin of the EMG pattern is a central programme, but afferent inputs can modulate the voluntary activity In this paper we also review the EMG and kinematic abnormalities that are present during the execution of single-joint rapid arm movements in patients with Parkinson's disease, Huntington's disease, Sydenham's chorea, dystonia, athetosis, cerebellar deficits, upper motor neuron syndrome, essential tremor and large-fibre sensory neuropathy. The data from these studies lead us to the following conclusions: (i) the basal ganglia have a role in scaling the size of AG1, reinforcing the voluntary command and inhibiting inappropriate EMG activity; (ii) the cerebellum has a role in timing the voluntary bursts and probably in implementing muscle force phasically; (iii) the corticospinal tract has a role in determining spatial and temporal recruitment of motor units; (iv) proprioceptive feedback is not necessary to produce the triphasic pattern but it contributes to the accuracy of both the trajectory and the end-point of rapid movements.

Original languageEnglish
Pages (from-to)661-674
Number of pages14
JournalBrain
Volume119
Issue number2
Publication statusPublished - 1996

Fingerprint

Joints
Muscles
Biomechanical Phenomena
Athetosis
Neurophysiological Recruitment
Essential Tremor
Chorea
Sensory Feedback
Pyramidal Tracts
Deceleration
Dystonia
Huntington Disease
Motor Neurons
Basal Ganglia
Cerebellum
Parkinson Disease
Motor Disorders
Inhibition (Psychology)

Keywords

  • Arm
  • Motor disorders
  • Normal subjects
  • Rapid movements

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Berardelli, A., Hallett, M., Rothwell, J. C., Agostino, R., Manfredi, M., Thompson, P. D., & Marsden, C. D. (1996). Single-joint rapid arm movements in normal subjects and in patients with motor disorders. Brain, 119(2), 661-674.

Single-joint rapid arm movements in normal subjects and in patients with motor disorders. / Berardelli, A.; Hallett, M.; Rothwell, J. C.; Agostino, R.; Manfredi, M.; Thompson, P. D.; Marsden, C. D.

In: Brain, Vol. 119, No. 2, 1996, p. 661-674.

Research output: Contribution to journalArticle

Berardelli, A, Hallett, M, Rothwell, JC, Agostino, R, Manfredi, M, Thompson, PD & Marsden, CD 1996, 'Single-joint rapid arm movements in normal subjects and in patients with motor disorders', Brain, vol. 119, no. 2, pp. 661-674.
Berardelli A, Hallett M, Rothwell JC, Agostino R, Manfredi M, Thompson PD et al. Single-joint rapid arm movements in normal subjects and in patients with motor disorders. Brain. 1996;119(2):661-674.
Berardelli, A. ; Hallett, M. ; Rothwell, J. C. ; Agostino, R. ; Manfredi, M. ; Thompson, P. D. ; Marsden, C. D. / Single-joint rapid arm movements in normal subjects and in patients with motor disorders. In: Brain. 1996 ; Vol. 119, No. 2. pp. 661-674.
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