Abstract
Gastric acidity of 12 patients with healed duodenal ulcers was continuously monitored over 24 h in order to assess the antisecretory effects of two different administration times of a single daily dose of ranitidine 300 mg. Each patient orally received either (a) placebo at 08.00 h and 22.00 h; (b) ranitidine 300 mg at 08.00 h and placebo at 22.00 h, or (c) placebo at 08.00 h and ranitidine 300 mg at 22.00 h in randomized and double-blind fashion. Each medication was administered on three separate occasions, with intervals of at least 1 week. Both the morning and the bedtime doses of ranitidine were significantly superior (p <0.001) to placebo in controlling 24-hour gastric acidity, while, in the same period, ranitidine nocte was more effective (p <0.001) than ranitidine mane. During the night, bedtime ranitidine caused more acid inhibition (p <0.001) than morning ranitidine, but the opposite (p <0.01) occurred during the daytime. This study shows that the antisecretory effect of morning ranitidine during the daytime is less consistent than that achieved by bedtime ranitidine during the nocturnal period. As similar rates of duodenal ulcer healing have recently been achieved with morning and conventional nighttime administration of Ho antagonists, it becomes clear that antisecretory drugs can also be beneficial with an acid inhibition which is shorter-lasting than that which was previously thought to be necessary or, alternatively, that also daytime acidity is important in ulcerogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 141-148 |
| Number of pages | 8 |
| Journal | Digestion |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Bedtime dose
- H<inf>2</inf> antagonists
- Morning dose
- PH monitoring
ASJC Scopus subject areas
- Gastroenterology
Cite this
Single morning and nightly doses of ranitidine 300 mg : An appraisal of their antisecretory effects by continuous ph monitoring1. / Savarino, Vincenzo; Mela, Giuseppe Sandro; Zentilin, Patrizia; Sumberaz, Alessandro; Cutela, Patrizia; Celle, Guido.
In: Digestion, Vol. 48, No. 3, 1991, p. 141-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single morning and nightly doses of ranitidine 300 mg
T2 - An appraisal of their antisecretory effects by continuous ph monitoring1
AU - Savarino, Vincenzo
AU - Mela, Giuseppe Sandro
AU - Zentilin, Patrizia
AU - Sumberaz, Alessandro
AU - Cutela, Patrizia
AU - Celle, Guido
PY - 1991
Y1 - 1991
N2 - Gastric acidity of 12 patients with healed duodenal ulcers was continuously monitored over 24 h in order to assess the antisecretory effects of two different administration times of a single daily dose of ranitidine 300 mg. Each patient orally received either (a) placebo at 08.00 h and 22.00 h; (b) ranitidine 300 mg at 08.00 h and placebo at 22.00 h, or (c) placebo at 08.00 h and ranitidine 300 mg at 22.00 h in randomized and double-blind fashion. Each medication was administered on three separate occasions, with intervals of at least 1 week. Both the morning and the bedtime doses of ranitidine were significantly superior (p <0.001) to placebo in controlling 24-hour gastric acidity, while, in the same period, ranitidine nocte was more effective (p <0.001) than ranitidine mane. During the night, bedtime ranitidine caused more acid inhibition (p <0.001) than morning ranitidine, but the opposite (p <0.01) occurred during the daytime. This study shows that the antisecretory effect of morning ranitidine during the daytime is less consistent than that achieved by bedtime ranitidine during the nocturnal period. As similar rates of duodenal ulcer healing have recently been achieved with morning and conventional nighttime administration of Ho antagonists, it becomes clear that antisecretory drugs can also be beneficial with an acid inhibition which is shorter-lasting than that which was previously thought to be necessary or, alternatively, that also daytime acidity is important in ulcerogenesis.
AB - Gastric acidity of 12 patients with healed duodenal ulcers was continuously monitored over 24 h in order to assess the antisecretory effects of two different administration times of a single daily dose of ranitidine 300 mg. Each patient orally received either (a) placebo at 08.00 h and 22.00 h; (b) ranitidine 300 mg at 08.00 h and placebo at 22.00 h, or (c) placebo at 08.00 h and ranitidine 300 mg at 22.00 h in randomized and double-blind fashion. Each medication was administered on three separate occasions, with intervals of at least 1 week. Both the morning and the bedtime doses of ranitidine were significantly superior (p <0.001) to placebo in controlling 24-hour gastric acidity, while, in the same period, ranitidine nocte was more effective (p <0.001) than ranitidine mane. During the night, bedtime ranitidine caused more acid inhibition (p <0.001) than morning ranitidine, but the opposite (p <0.01) occurred during the daytime. This study shows that the antisecretory effect of morning ranitidine during the daytime is less consistent than that achieved by bedtime ranitidine during the nocturnal period. As similar rates of duodenal ulcer healing have recently been achieved with morning and conventional nighttime administration of Ho antagonists, it becomes clear that antisecretory drugs can also be beneficial with an acid inhibition which is shorter-lasting than that which was previously thought to be necessary or, alternatively, that also daytime acidity is important in ulcerogenesis.
KW - Bedtime dose
KW - H<inf>2</inf> antagonists
KW - Morning dose
KW - PH monitoring
UR - http://www.scopus.com/inward/record.url?scp=0025873584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025873584&partnerID=8YFLogxK
U2 - 10.1159/000200686
DO - 10.1159/000200686
M3 - Article
C2 - 1916034
AN - SCOPUS:0025873584
VL - 48
SP - 141
EP - 148
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 3
ER -