Single-nucleotide polymorphisms in human β-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters

Silvia Baroncelli, Elisabetta Ricci, Mauro Andreotti, Giovanni Guidotti, Paola Germano, Maria Cristina Marazzi, Stefano Vella, Leonardo Palombi, Anita De Rossi, Marina Giuliano

Research output: Contribution to journalArticle

Abstract

We analyzed single nucleotide polymorphisms in the 5′-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of β-defensins could have an impact on viral replication in breast milk.

Original languageEnglish
Pages (from-to)1515-1517
Number of pages3
JournalAIDS (London, England)
Volume22
Issue number12
DOIs
Publication statusPublished - Jul 31 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases
  • Medicine(all)

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    Baroncelli, S., Ricci, E., Andreotti, M., Guidotti, G., Germano, P., Marazzi, M. C., Vella, S., Palombi, L., De Rossi, A., & Giuliano, M. (2008). Single-nucleotide polymorphisms in human β-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters. AIDS (London, England), 22(12), 1515-1517. https://doi.org/10.1097/QAD.0b013e3282fd6e0c