Single olfactory organ associated with prosencephalic malformation and cyclopia in a Xenopus laevis tadpole

Lorenzo Magrassi, Pasquale P C Graziadei

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A cyclops Xenopus laevis tadpole with a single olfactory organ is described. At a stage comparable to 48, the telencephalon was severely atrophic and only the region where the olfactory fibres terminated appeared to have the cytoarchitecture of the olfactory bulb. In this animal the central nervous system (CNS) appeared normally developed only posterior to the preoptic area. The hypothesis of a diencephalic origin of the region where the olfactory fibres terminated is discussed in the light of our previous results of olfactory placode transplantation. By analogy between this case and other malformations (cyclopia, holoprosencephaly) in higher vertebrates and humans, the need is emphasized for a more precise anatomical description of the olfactory input in related malformations.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalBrain Research
Issue number2
Publication statusPublished - Jun 2 1987



  • Amphibian
  • Cyclopia
  • Malformation
  • Olfactory organ
  • Prosencephalon

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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