Abstract
Current diagnostic criteria for Parkinson's disease (PD) rely on the presence of motor signs, but it is now evident that they require months or years to become clinically manifest. By contrast, initial manifestations of PD may involve several nonmotor domains, such as cognition, mood, smell or sleep, and their recognition is critical if one is aiming for early diagnosis to provide neuroprotection. In this context, imaging tracers are gaining relevance as they are increasingly recognized as biological markers of disease progression. In this review, we will discuss the role of single photon-emission computed tomography imaging in the early phases of PD and in the differential diagnosis of essential tremor and atypical parkinsonism. We will also discuss the role of imaging of monoaminergic nondopamine systems to assess nonmotor features.
| Original language | English |
|---|---|
| Pages (from-to) | 1853-1864 |
| Number of pages | 12 |
| Journal | Expert Review of Neurotherapeutics |
| Volume | 8 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- Dopamine transporter
- Essential tremor
- Parkinson's disease
- Perfusion tracer
- SPECT
ASJC Scopus subject areas
- Clinical Neurology
- Pharmacology (medical)
- Neuroscience(all)
Cite this
Single photon-emission computed tomography imaging in early Parkinson's disease. / Antonini, Angelo; Isaias, Ioannis U.
In: Expert Review of Neurotherapeutics, Vol. 8, No. 12, 12.2008, p. 1853-1864.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single photon-emission computed tomography imaging in early Parkinson's disease
AU - Antonini, Angelo
AU - Isaias, Ioannis U.
PY - 2008/12
Y1 - 2008/12
N2 - Current diagnostic criteria for Parkinson's disease (PD) rely on the presence of motor signs, but it is now evident that they require months or years to become clinically manifest. By contrast, initial manifestations of PD may involve several nonmotor domains, such as cognition, mood, smell or sleep, and their recognition is critical if one is aiming for early diagnosis to provide neuroprotection. In this context, imaging tracers are gaining relevance as they are increasingly recognized as biological markers of disease progression. In this review, we will discuss the role of single photon-emission computed tomography imaging in the early phases of PD and in the differential diagnosis of essential tremor and atypical parkinsonism. We will also discuss the role of imaging of monoaminergic nondopamine systems to assess nonmotor features.
AB - Current diagnostic criteria for Parkinson's disease (PD) rely on the presence of motor signs, but it is now evident that they require months or years to become clinically manifest. By contrast, initial manifestations of PD may involve several nonmotor domains, such as cognition, mood, smell or sleep, and their recognition is critical if one is aiming for early diagnosis to provide neuroprotection. In this context, imaging tracers are gaining relevance as they are increasingly recognized as biological markers of disease progression. In this review, we will discuss the role of single photon-emission computed tomography imaging in the early phases of PD and in the differential diagnosis of essential tremor and atypical parkinsonism. We will also discuss the role of imaging of monoaminergic nondopamine systems to assess nonmotor features.
KW - Dopamine transporter
KW - Essential tremor
KW - Parkinson's disease
KW - Perfusion tracer
KW - SPECT
UR - http://www.scopus.com/inward/record.url?scp=57749182221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749182221&partnerID=8YFLogxK
U2 - 10.1586/14737175.8.12.1853
DO - 10.1586/14737175.8.12.1853
M3 - Article
C2 - 19086881
AN - SCOPUS:57749182221
VL - 8
SP - 1853
EP - 1864
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
SN - 1473-7175
IS - 12
ER -