Single photon emission computed tomography with [99Tc]-HM-PAO and [123I]-IBZM in Alzheimer's disease and dementia of frontal type: Preliminary results

G. B. Frisoni, G. Pizzolato, A. Bianchetti, F. Chierichetti, G. Ferlin, L. Battistin, M. Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Dementia of frontal type (DFT) is a fairly common degenerative disease distinct from Alzheimer's disease (AD), whose reportedly distinctive instrumental feature is frontal lobe hypoperfusion on SPECT. We evaluated the cortical dopaminergic system in 6 AD, 5 DFT, and 6 control subjects with SPECT and both [99Tc]-HM-PAO, a perfusion tracer, and [123I]-IBZM, a D2 postsynaptic ligand. Both in AD and DFT patients, [99Tc]-HM-PAO SPECT showed a relative frontal hypoperfusion. On the contrary, [123I]-IBZM SPECT showed significantly reduced ligand uptake in superior frontal regions of DFT (0.89 ± 0.08 relative to control subjects) as compared to AD patients (0.97 ± 0.02; difference of means; 0.08, 95% Confidence Interval 0.004 to 0.156; p=0.041). Results suggest more marked involvement of the frontal cortical dopaminergic system in DFT than in AD patients.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalActa Neurologica Scandinavica
Volume89
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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