Single photon emission computerized tomography increases the sensitivity of indium-111-pentetreotide scintigraphy in detecting abdominal carcinoids

Orazio Schillaci, Francesco Scopinaro, Roberta Danieli, Stefano Angeletti, Rosanna Tavolaro, Bruno Annibale, Pina Cannas, Massimo Marignani, Antonio Centi Colella, Gianfranco Delle Fave

Research output: Contribution to journalArticlepeer-review

Abstract

Somatostatin (sms) receptors have been identified in carcinoids (c), so enabling their visualization with 111In-pentetreotide scintigraphy. The aim of this study was to evaluate if single photon emission computerized tomography (SPECT) can increase the sensitivity of sms receptor scintigraphy in the detection of abdominal c. 26 patients (pts) with a present, or previously operated, abdominal carcinoid were submitted to SPECT over the abdomen and multiple planar views after the injection of 111In-pentetreotide. Magnetic resonance imaging and computed tomography were also performed. In 19 pts abnormal sites of uptake were found by SPECT which localized 13 abdominal extrahepatic (11 pts) and 45 hepatic lesions (in 15 pts). No pathologic accumulation was seen in 7 pts in complete remission after surgery. Planar images visualized 7 abdominal extrahepatic (in 6 pts) and 26 liver tumor sites (in 10 pts), conventional procedures detected 5 abdominal extrahepatic (in 4 pts) and 36 hepatic lesions (in 10 pts). 111In-pentetreotide SPECT is more sensitive than planar scanning and conventional methods to detect abdominal c, and so may play a major role in the early and accurate mapping of tumour spread.

Original languageEnglish
Pages (from-to)1753-1756
Number of pages4
JournalAnticancer Research
Volume17
Issue number3 B
Publication statusPublished - 1997

Keywords

  • Abdominal carcinoids
  • Computed tomography
  • Indium-111-pentetreotide
  • Magnetic resonance imaging
  • Single photon emission computerized tomography
  • Somatostatin receptor scintigraphy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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