Single photon emission computerized tomography (SPECT) in epilepsies: A multicentric study

G. Avanzini, R. Canger, M. Franceschi, L. Murri, G. L. Spreafico, M. Casazza, R. Spreafico, L. Tassi, C. Messa, L. Ferini-Strambi, A. Nuti, P. Bertelli

Research output: Chapter in Book/Report/Conference proceedingChapter


The SPECT image of 99T cm-HMPAO (99, TC-Hexamethylpropyleneaminaoxime) distribution gives a suitable estimation of regional blood flow (rCBF) distribution. In a multicentric study carried out in Italy the SPECT examination was performed in 91 patients selected according to the following criteria: adult subjects with partial epilepsies of unknown origin showing normal neurological and CAT examinations. Regional asymmetries in HMPAO cerebral fixation were detected in 46 out of 91 cases. A good topographic concordance between regional HMPAO hypofixations and EEG foci was found in 28 out of 76 patients presenting with a focal EEG. In addition a good SPECT-MR concordance was found in 10 out of 20 patients who showed pathological MR findings. The results demonstrate the existance of a detectable rCBF defect in epileptic foci defined on clinical and/or EEG criteria with no evidence of cerebral lesion according to clinical and TAC examinations. Further studies on larger case series are needed to assess the clinical value of SPECT examination in patients with epilepsy.

Original languageEnglish
Title of host publicationBollettino - Lega Italiana contro l'Epilessia
Number of pages8
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Neurology


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