Single stranded DNA-vectors for analyzing processing of DNA damage induced by 4-nitroquinoline-1-oxide in prokaryotes and eukaryotes.

R. Iannone, P. Campomenosi, C. Madzak, A. Inga, F. Caocci, A. Abbondandolo, G. Fronza, A. Sarasin

Research output: Contribution to journalArticle

Abstract

Previous studies indicate that single stranded DNA vectors could be used in different organisms to study mutagenesis induced by DNA damaging agents. We applied this approach to study mutagenesis induced by 4NQO lesions. The use of ssDNA, on which the ultimate metabolite of 4NQO (Ac-4HAQO) induces mainly C8-guanine adducts, allowed us to find a correlation between G-transversions and the dGuo-C8-AQO adduct. This correlation was established in two independent assay-systems, based on prokaryotic and eukaryotic cells.

Original languageEnglish
Pages (from-to)619-624
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume68
Issue number10
Publication statusPublished - Oct 1992

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ASJC Scopus subject areas

  • Medicine(all)

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