Istiocitosi dei seni con massiva linfoadenopatia cervicale (malattia di Rosai-Dorfman)

Translated title of the contribution: Sinus histiocytosis with massive cervical lymphadenopathy (Rosai-Dorfman disease)

F. Ferrario, A. Macchi, G. Spriano, R. Piantanida, M. Bonato

Research output: Contribution to journalArticlepeer-review


Sinus histiocytosis with massive lymphadenopathy (SHML) was firstly described by Rosai and Dorfman in 1969. It is considered an idiopathic disease which usually occurs with a slowly growing and asymptomatic lymphnodal mass, appearing in the cervical area in the 90% of the cases. From the histological standpoint it is characterized by a remarkable dilatation of the lymphatic sinuses due to the proliferation of some peculiar histiocytes. The Authors report a case of SHML involving all the neck lymph nodes and the nasopharynx, whose clinical patterns showed some difficulties in differentiating it from a lymphoma. A definitive lymphadenectomy was necessary for the final diagnosis while repeated biopsies of the mucosal localization did not allow a certain interpretation.

Translated title of the contributionSinus histiocytosis with massive cervical lymphadenopathy (Rosai-Dorfman disease)
Original languageItalian
Pages (from-to)35-39
Number of pages5
Issue number1
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Otorhinolaryngology


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