Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case

M. Paulli, F. Locatelli, S. Kindl, E. Boveri, F. Facchetti, F. Porta, R. Rosso, L. Nespoli, U. Magrini

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to themacrophage - histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteristics of the histiocyte-like cells in one paediatric case of SHML (also named Rosai-Dorfman disease). The SHML cells expressed the S-100 protein, lectins concanavalin A, peanut agglutinin andmonocyte-macrophage related antigens CD 11c, CD 14, CD 33, CD 68 and LN 5. Reactivity with other anti-macrophage antibodies (MAC 387, lysozyme, alpha-1 anti-chymotrypsin) was variable. The CD1a antigen was present only in scattered cells, whereas HLA-DR and the HLA-DR associated invariant chain were absent. Cytochemistry demonstrated an intense activity of acid phosphatase and non specific esterase of SHML cells. A large amount of medium sized mononuclear cells were located in the sinuses and intersinusoidal tissue. Our findings suggest that SHML cells have intermediate features between phagocytes and Langerhans cells/interdigitating reticulum cells. The heterogeneity of marker expression on SHML cells might be related to the local content of factors (e.g., cytokines), capable of modulating the phenotype of monocyted and derived cells.

Original languageEnglish
Pages (from-to)672-675
Number of pages4
JournalEuropean Journal of Pediatrics
Volume151
Issue number9
DOIs
Publication statusPublished - Sep 1992

Fingerprint

Sinus Histiocytosis
Pediatrics
Histiocytes
HLA-DR Antigens
CD Antigens
Macrophages
Peanut Agglutinin
Histocytochemistry
Reticulum
Carboxylesterase
Langerhans Cells
S100 Proteins
Chymotrypsin
Phagocytes
Muramidase
Concanavalin A
Acid Phosphatase
Lectins
Dendritic Cells
Anti-Idiotypic Antibodies

Keywords

  • Immunohistochemistry
  • Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case. / Paulli, M.; Locatelli, F.; Kindl, S.; Boveri, E.; Facchetti, F.; Porta, F.; Rosso, R.; Nespoli, L.; Magrini, U.

In: European Journal of Pediatrics, Vol. 151, No. 9, 09.1992, p. 672-675.

Research output: Contribution to journalArticle

@article{cb0cd5f529d047b49f1056069f980d6d,
title = "Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case",
abstract = "Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to themacrophage - histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteristics of the histiocyte-like cells in one paediatric case of SHML (also named Rosai-Dorfman disease). The SHML cells expressed the S-100 protein, lectins concanavalin A, peanut agglutinin andmonocyte-macrophage related antigens CD 11c, CD 14, CD 33, CD 68 and LN 5. Reactivity with other anti-macrophage antibodies (MAC 387, lysozyme, alpha-1 anti-chymotrypsin) was variable. The CD1a antigen was present only in scattered cells, whereas HLA-DR and the HLA-DR associated invariant chain were absent. Cytochemistry demonstrated an intense activity of acid phosphatase and non specific esterase of SHML cells. A large amount of medium sized mononuclear cells were located in the sinuses and intersinusoidal tissue. Our findings suggest that SHML cells have intermediate features between phagocytes and Langerhans cells/interdigitating reticulum cells. The heterogeneity of marker expression on SHML cells might be related to the local content of factors (e.g., cytokines), capable of modulating the phenotype of monocyted and derived cells.",
keywords = "Immunohistochemistry, Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease)",
author = "M. Paulli and F. Locatelli and S. Kindl and E. Boveri and F. Facchetti and F. Porta and R. Rosso and L. Nespoli and U. Magrini",
year = "1992",
month = "9",
doi = "10.1007/BF01957571",
language = "English",
volume = "151",
pages = "672--675",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Berlin Heidelberg",
number = "9",

}

TY - JOUR

T1 - Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease). Clinico-pathological analysis of a paediatric case

AU - Paulli, M.

AU - Locatelli, F.

AU - Kindl, S.

AU - Boveri, E.

AU - Facchetti, F.

AU - Porta, F.

AU - Rosso, R.

AU - Nespoli, L.

AU - Magrini, U.

PY - 1992/9

Y1 - 1992/9

N2 - Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to themacrophage - histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteristics of the histiocyte-like cells in one paediatric case of SHML (also named Rosai-Dorfman disease). The SHML cells expressed the S-100 protein, lectins concanavalin A, peanut agglutinin andmonocyte-macrophage related antigens CD 11c, CD 14, CD 33, CD 68 and LN 5. Reactivity with other anti-macrophage antibodies (MAC 387, lysozyme, alpha-1 anti-chymotrypsin) was variable. The CD1a antigen was present only in scattered cells, whereas HLA-DR and the HLA-DR associated invariant chain were absent. Cytochemistry demonstrated an intense activity of acid phosphatase and non specific esterase of SHML cells. A large amount of medium sized mononuclear cells were located in the sinuses and intersinusoidal tissue. Our findings suggest that SHML cells have intermediate features between phagocytes and Langerhans cells/interdigitating reticulum cells. The heterogeneity of marker expression on SHML cells might be related to the local content of factors (e.g., cytokines), capable of modulating the phenotype of monocyted and derived cells.

AB - Histochemical and immunohistochemical studies performed in only a few cases of sinus histiocytosis with massive lymphoadenopathy (SHML) indicated that SHML cells belong to themacrophage - histiocyte system, though their exact origin is still uncertain. We analyzed the morphological, antigenic and enzymatic characteristics of the histiocyte-like cells in one paediatric case of SHML (also named Rosai-Dorfman disease). The SHML cells expressed the S-100 protein, lectins concanavalin A, peanut agglutinin andmonocyte-macrophage related antigens CD 11c, CD 14, CD 33, CD 68 and LN 5. Reactivity with other anti-macrophage antibodies (MAC 387, lysozyme, alpha-1 anti-chymotrypsin) was variable. The CD1a antigen was present only in scattered cells, whereas HLA-DR and the HLA-DR associated invariant chain were absent. Cytochemistry demonstrated an intense activity of acid phosphatase and non specific esterase of SHML cells. A large amount of medium sized mononuclear cells were located in the sinuses and intersinusoidal tissue. Our findings suggest that SHML cells have intermediate features between phagocytes and Langerhans cells/interdigitating reticulum cells. The heterogeneity of marker expression on SHML cells might be related to the local content of factors (e.g., cytokines), capable of modulating the phenotype of monocyted and derived cells.

KW - Immunohistochemistry

KW - Sinus histiocytosis with massive lymphoadenopathy (Rosai-Dorfman disease)

UR - http://www.scopus.com/inward/record.url?scp=0026769552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026769552&partnerID=8YFLogxK

U2 - 10.1007/BF01957571

DO - 10.1007/BF01957571

M3 - Article

C2 - 1341420

AN - SCOPUS:0026769552

VL - 151

SP - 672

EP - 675

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 9

ER -