SiO2 entrapment of animal cells for hybrid bioartificial organs

G. Carturan, R. Dal Monte, M. Muraca

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Si-alkoxides in gas phase are reactive towards the surface of animal cells, depositing a homogeneous layer of porous silica. This encapsulation method preserves cell viability and does not alter the hindrance of the biological load. In the prospective use for the design of a hybrid bioartificial liver, hepatocytes in a collagen matrix can be entrapped by the siliceous deposit which provides definite mechanical stability to the collagen matrix and molecular cutoff vs. high molecular weight proteins, including immunoglobulins. The functionality of the encapsulated cell load is maintained for the expressions of typical liver and pancreas metabolic activities.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium - Proceedings
EditorsR.M. Laine, C. Sanchez, C.J. Brinker, E. Giannelis
Volume628
Publication statusPublished - 2000
EventOrganic/Inorganic Hybrid Materials-2000 - San Francisco, CA, United States
Duration: Apr 24 2000Apr 28 2000

Other

OtherOrganic/Inorganic Hybrid Materials-2000
CountryUnited States
CitySan Francisco, CA
Period4/24/004/28/00

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Carturan, G., Dal Monte, R., & Muraca, M. (2000). SiO2 entrapment of animal cells for hybrid bioartificial organs. In R. M. Laine, C. Sanchez, C. J. Brinker, & E. Giannelis (Eds.), Materials Research Society Symposium - Proceedings (Vol. 628)