SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy

SIOPE BTG Radiotherapy Group

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy.

METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution.

RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV.

CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalRadiotherapy and Oncology
Volume128
Issue number2
DOIs
Publication statusPublished - Aug 2018

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Brain Neoplasms
Radiotherapy
Guidelines
Optic Nerve
Ethmoid Bone
Subarachnoid Space
Cranial Nerves
Dental Pulp Cavity
Cochlea
Skull Base
Temporal Lobe
Young Adult
Magnetic Resonance Imaging
Pediatrics
Recurrence
Brain
Radiation Oncologists

Keywords

  • Adult
  • Brain/diagnostic imaging
  • Brain Neoplasms/diagnostic imaging
  • Child
  • Consensus
  • Female
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Radiotherapy Planning, Computer-Assisted/methods
  • Young Adult

Cite this

SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy. / SIOPE BTG Radiotherapy Group.

In: Radiotherapy and Oncology, Vol. 128, No. 2, 08.2018, p. 192-197.

Research output: Contribution to journalArticle

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title = "SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy",
abstract = "OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy.METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution.RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV.CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.",
keywords = "Adult, Brain/diagnostic imaging, Brain Neoplasms/diagnostic imaging, Child, Consensus, Female, Humans, Magnetic Resonance Imaging/methods, Male, Radiotherapy Planning, Computer-Assisted/methods, Young Adult",
author = "Thankamma Ajithkumar and Gail Horan and Laetitia Padovani and Nicky Thorp and Beate Timmermann and Claire Alapetite and Lorenza Gandola and Monica Ramos and {Van Beek}, Karen and Melissa Christiaens and Yasmin Lassen-Ramshad and Henriette Magelssen and Kristina Nilsson and Frank Saran and Barbara Rombi and Rolf Kortmann and Janssens, {Geert O} and {SIOPE BTG Radiotherapy Group}",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = "8",
doi = "10.1016/j.radonc.2018.04.016",
language = "English",
volume = "128",
pages = "192--197",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
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number = "2",

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TY - JOUR

T1 - SIOPE - Brain tumor group consensus guideline on craniospinal target volume delineation for high-precision radiotherapy

AU - Ajithkumar, Thankamma

AU - Horan, Gail

AU - Padovani, Laetitia

AU - Thorp, Nicky

AU - Timmermann, Beate

AU - Alapetite, Claire

AU - Gandola, Lorenza

AU - Ramos, Monica

AU - Van Beek, Karen

AU - Christiaens, Melissa

AU - Lassen-Ramshad, Yasmin

AU - Magelssen, Henriette

AU - Nilsson, Kristina

AU - Saran, Frank

AU - Rombi, Barbara

AU - Kortmann, Rolf

AU - Janssens, Geert O

AU - SIOPE BTG Radiotherapy Group

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy.METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution.RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV.CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.

AB - OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy.METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution.RESULTS: The CTVcranial should include the whole brain, cribriform plate, most inferior part of the temporal lobes, and the pituitary fossa. If the full length of both optic nerves is not included, the dose received by different volumes of optic nerve should be recorded to correlate with future patterns of relapse (no consensus). The CTVcranial should be modified to include the dural cuffs of cranial nerves as they pass through the skull base foramina. Attempts to spare the cochlea by excluding CSF within the internal auditory canal should be avoided. The CTVspinal should include the entire subarachnoid space, including nerve roots laterally. The lower limit of the spinal CTV is at the lower limit of the thecal sac, best visible on MRI scan. There is no need to include sacral root canals in the spinal CTV.CONCLUSION: This consensus guideline has the potential to improve consistency of craniospinal TV delineation in an era of high-precision radiotherapy. This proposal will be incorporated in the RTQA guidelines of future SIOPE-BTG trials using CSI.

KW - Adult

KW - Brain/diagnostic imaging

KW - Brain Neoplasms/diagnostic imaging

KW - Child

KW - Consensus

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Radiotherapy Planning, Computer-Assisted/methods

KW - Young Adult

U2 - 10.1016/j.radonc.2018.04.016

DO - 10.1016/j.radonc.2018.04.016

M3 - Article

C2 - 29729847

VL - 128

SP - 192

EP - 197

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 2

ER -