SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Francesca Tavano, Valerio Pazienza, Andrea Fontana, Francesca Paola Burbaci, Concita Panebianco, Chiara Saracino, Lucia Lombardi, Antonio De Bonis, Fabio Francesco Di Mola, Pierluigi Di Sebastiano, Ada Piepoli, Manlio Vinciguerra, Massimo Fracavilla, Francesco Giuliani, Rosa Rubino, Angelo Andriulli, Gianluigi Mazzoccoli

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p

Original languageEnglish
Pages (from-to)497-512
Number of pages16
JournalChronobiology International
Volume32
Issue number4
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Cancer
  • Circadian
  • Clock gene
  • Pancreas
  • Rhythm
  • SIRT1

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Tavano, F., Pazienza, V., Fontana, A., Burbaci, F. P., Panebianco, C., Saracino, C., Lombardi, L., De Bonis, A., Di Mola, F. F., Di Sebastiano, P., Piepoli, A., Vinciguerra, M., Fracavilla, M., Giuliani, F., Rubino, R., Andriulli, A., & Mazzoccoli, G. (2015). SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. Chronobiology International, 32(4), 497-512. https://doi.org/10.3109/07420528.2014.1003351