SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Francesca Tavano; Valerio Pazienza; Andrea Fontana; Francesca Paola Burbaci; Concita Panebianco; Chiara Saracino; Lucia Lombardi; Antonio De Bonis; Fabio Francesco Di Mola; Pierluigi Di Sebastiano; Ada Piepoli; Manlio Vinciguerra; Massimo Fracavilla; Francesco Giuliani; Rosa Rubino; Angelo Andriulli; Gianluigi Mazzoccoli

doi:10.3109/07420528.2014.1003351

SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Francesca Tavano, Valerio Pazienza, Andrea Fontana, Francesca Paola Burbaci, Concita Panebianco, Chiara Saracino, Lucia Lombardi, Antonio De Bonis, Fabio Francesco Di Mola, Pierluigi Di Sebastiano, Ada Piepoli, Manlio Vinciguerra, Massimo Fracavilla, Francesco Giuliani, Rosa Rubino, Angelo Andriulli, Gianluigi Mazzoccoli

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article

Abstract

Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p

Original language	English
Pages (from-to)	497-512
Number of pages	16
Journal	Chronobiology International
Volume	32
Issue number	4
DOIs	https://doi.org/10.3109/07420528.2014.1003351
Publication status	Published - May 1 2015

Keywords

Cancer
Circadian
Clock gene
Pancreas
Rhythm
SIRT1

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.3109/07420528.2014.1003351

Fingerprint Dive into the research topics of 'SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation'. Together they form a unique fingerprint.

Cite this

Tavano, F., Pazienza, V., Fontana, A., Burbaci, F. P., Panebianco, C., Saracino, C., Lombardi, L., De Bonis, A., Di Mola, F. F., Di Sebastiano, P., Piepoli, A., Vinciguerra, M., Fracavilla, M., Giuliani, F., Rubino, R., Andriulli, A., & Mazzoccoli, G. (2015). SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. Chronobiology International, 32(4), 497-512. https://doi.org/10.3109/07420528.2014.1003351

SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma : Effect of starvation. / Tavano, Francesca ; Pazienza, Valerio; Fontana, Andrea; Burbaci, Francesca Paola; Panebianco, Concita; Saracino, Chiara; Lombardi, Lucia; De Bonis, Antonio; Di Mola, Fabio Francesco; Di Sebastiano, Pierluigi; Piepoli, Ada; Vinciguerra, Manlio; Fracavilla, Massimo; Giuliani, Francesco; Rubino, Rosa; Andriulli, Angelo ; Mazzoccoli, Gianluigi.

In: Chronobiology International, Vol. 32, No. 4, 01.05.2015, p. 497-512.

Research output: Contribution to journal › Article

Tavano, F , Pazienza, V, Fontana, A, Burbaci, FP, Panebianco, C, Saracino, C, Lombardi, L, De Bonis, A, Di Mola, FF, Di Sebastiano, P, Piepoli, A, Vinciguerra, M, Fracavilla, M, Giuliani, F, Rubino, R, Andriulli, A & Mazzoccoli, G 2015, 'SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation', Chronobiology International, vol. 32, no. 4, pp. 497-512. https://doi.org/10.3109/07420528.2014.1003351

Tavano, Francesca ; Pazienza, Valerio ; Fontana, Andrea ; Burbaci, Francesca Paola ; Panebianco, Concita ; Saracino, Chiara ; Lombardi, Lucia ; De Bonis, Antonio ; Di Mola, Fabio Francesco ; Di Sebastiano, Pierluigi ; Piepoli, Ada ; Vinciguerra, Manlio ; Fracavilla, Massimo ; Giuliani, Francesco ; Rubino, Rosa ; Andriulli, Angelo ; Mazzoccoli, Gianluigi. / SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma : Effect of starvation. In: Chronobiology International. 2015 ; Vol. 32, No. 4. pp. 497-512.

@article{1769fd950cfc48e3ad1b5e6b2c49daf1,

title = "SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation",

abstract = "Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p",

keywords = "Cancer, Circadian, Clock gene, Pancreas, Rhythm, SIRT1",

author = "Francesca Tavano and Valerio Pazienza and Andrea Fontana and Burbaci, {Francesca Paola} and Concita Panebianco and Chiara Saracino and Lucia Lombardi and {De Bonis}, Antonio and {Di Mola}, {Fabio Francesco} and {Di Sebastiano}, Pierluigi and Ada Piepoli and Manlio Vinciguerra and Massimo Fracavilla and Francesco Giuliani and Rosa Rubino and Angelo Andriulli and Gianluigi Mazzoccoli",

year = "2015",

month = may,

day = "1",

doi = "10.3109/07420528.2014.1003351",

language = "English",

volume = "32",

pages = "497--512",

journal = "Annual Review of Chronopharmacology",

issn = "0742-0528",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma

T2 - Effect of starvation

AU - Tavano, Francesca

AU - Pazienza, Valerio

AU - Fontana, Andrea

AU - Burbaci, Francesca Paola

AU - Panebianco, Concita

AU - Saracino, Chiara

AU - Lombardi, Lucia

AU - De Bonis, Antonio

AU - Di Mola, Fabio Francesco

AU - Di Sebastiano, Pierluigi

AU - Piepoli, Ada

AU - Vinciguerra, Manlio

AU - Fracavilla, Massimo

AU - Giuliani, Francesco

AU - Rubino, Rosa

AU - Andriulli, Angelo

AU - Mazzoccoli, Gianluigi

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p

AB - Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p

KW - Cancer

KW - Circadian

KW - Clock gene

KW - Pancreas

KW - Rhythm

KW - SIRT1

UR - http://www.scopus.com/inward/record.url?scp=84928886774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928886774&partnerID=8YFLogxK

U2 - 10.3109/07420528.2014.1003351

DO - 10.3109/07420528.2014.1003351

M3 - Article

C2 - 25798752

AN - SCOPUS:84928886774

VL - 32

SP - 497

EP - 512

JO - Annual Review of Chronopharmacology

JF - Annual Review of Chronopharmacology

SN - 0742-0528

IS - 4

ER -