SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Francesca Tavano; Valerio Pazienza; Andrea Fontana; Francesca Paola Burbaci; Concita Panebianco; Chiara Saracino; Lucia Lombardi; Antonio De Bonis; Fabio Francesco Di Mola; Pierluigi Di Sebastiano; Ada Piepoli; Manlio Vinciguerra; Massimo Fracavilla; Francesco Giuliani; Rosa Rubino; Angelo Andriulli; Gianluigi Mazzoccoli

doi:10.3109/07420528.2014.1003351

SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Francesca Tavano, Valerio Pazienza, Andrea Fontana, Francesca Paola Burbaci, Concita Panebianco, Chiara Saracino, Lucia Lombardi, Antonio De Bonis, Fabio Francesco Di Mola, Pierluigi Di Sebastiano, Ada Piepoli, Manlio Vinciguerra, Massimo Fracavilla, Francesco Giuliani, Rosa Rubino, Angelo Andriulli, Gianluigi Mazzoccoli

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p

Original language	English
Pages (from-to)	497-512
Number of pages	16
Journal	Chronobiology International
Volume	32
Issue number	4
DOIs	https://doi.org/10.3109/07420528.2014.1003351
Publication status	Published - May 1 2015

Keywords

Cancer
Circadian
Clock gene
Pancreas
Rhythm
SIRT1

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.3109/07420528.2014.1003351

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Tavano, F., Pazienza, V., Fontana, A., Burbaci, F. P., Panebianco, C., Saracino, C., Lombardi, L., De Bonis, A., Di Mola, F. F., Di Sebastiano, P., Piepoli, A., Vinciguerra, M., Fracavilla, M., Giuliani, F., Rubino, R., Andriulli, A., & Mazzoccoli, G. (2015). SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. Chronobiology International, 32(4), 497-512. https://doi.org/10.3109/07420528.2014.1003351

Tavano, F , Pazienza, V , Fontana, A, Burbaci, FP, Panebianco, C, Saracino, C, Lombardi, L, De Bonis, A, Di Mola, FF, Di Sebastiano, P, Piepoli, A, Vinciguerra, M, Fracavilla, M, Giuliani, F, Rubino, R, Andriulli, A & Mazzoccoli, G 2015, 'SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation', Chronobiology International, vol. 32, no. 4, pp. 497-512. https://doi.org/10.3109/07420528.2014.1003351

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AU - Panebianco, Concita

AU - Saracino, Chiara

AU - Lombardi, Lucia

AU - De Bonis, Antonio

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AU - Di Sebastiano, Pierluigi

AU - Piepoli, Ada

AU - Vinciguerra, Manlio

AU - Fracavilla, Massimo

AU - Giuliani, Francesco

AU - Rubino, Rosa

AU - Andriulli, Angelo

AU - Mazzoccoli, Gianluigi

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SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation

Abstract

Keywords

ASJC Scopus subject areas

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