TY - JOUR
T1 - SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma
T2 - Effect of starvation
AU - Tavano, Francesca
AU - Pazienza, Valerio
AU - Fontana, Andrea
AU - Burbaci, Francesca Paola
AU - Panebianco, Concita
AU - Saracino, Chiara
AU - Lombardi, Lucia
AU - De Bonis, Antonio
AU - Di Mola, Fabio Francesco
AU - Di Sebastiano, Pierluigi
AU - Piepoli, Ada
AU - Vinciguerra, Manlio
AU - Fracavilla, Massimo
AU - Giuliani, Francesco
AU - Rubino, Rosa
AU - Andriulli, Angelo
AU - Mazzoccoli, Gianluigi
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p
AB - Pancreatic cancer (PC), the fourth leading cause of cancer-related deaths, is characterized by high aggressiveness and resistance to chemotherapy. Pancreatic carcinogenesis is kept going by derangement of essential cell processes, such as proliferation, apoptosis, metabolism and autophagy, characterized by rhythmic variations with 24-h periodicity driven by the biological clock. We assessed the expression of the circadian genes ARNLT, ARNLT2, CLOCK, PER1, PER2, PER3, CRY1, CRY2 and the starvation-activated histone/protein deacetylase SIRT1 in 34 matched tumor and non-tumor tissue specimens of PC patients, and evaluated in PC derived cell lines if the modulation of SIRT1 expression through starvation could influence the temporal pattern of expression of the circadian genes. We found a significant down-regulation of ARNLT (p=0.015), CRY1 (p=0.013), CRY2 (p=0.001), PER1 (p
KW - Cancer
KW - Circadian
KW - Clock gene
KW - Pancreas
KW - Rhythm
KW - SIRT1
UR - http://www.scopus.com/inward/record.url?scp=84928886774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928886774&partnerID=8YFLogxK
U2 - 10.3109/07420528.2014.1003351
DO - 10.3109/07420528.2014.1003351
M3 - Article
C2 - 25798752
AN - SCOPUS:84928886774
VL - 32
SP - 497
EP - 512
JO - Annual Review of Chronopharmacology
JF - Annual Review of Chronopharmacology
SN - 0742-0528
IS - 4
ER -