SIRT1 and the clock gene machinery in colorectal cancer

Valerio Pazienza, Ada Piepoli, Anna Panza, Maria Rosa Valvano, Giorgia Benegiamo, Manlio Vinciguerra, Angelo Andriulli, Gianluigi Mazzoccoli

Research output: Contribution to journalArticlepeer-review

Abstract

SIRT1 and the clock genes are involved in carcinogenesis. We evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells. In CRC, SIRT1 mean expression level was decreased. Compared to CaCo2 cells, SW480 cells displayed lower levels of SIRT1 and PER3 and higher levels of ARNTL1, CLOCK, PER1, PER2, CRY1, TIPIN, and CSNKIE. SIRT1 overexpression induced PER1 upregulation in CaCo2 and downregulation in SW480 cells. SIRT1 expression was heterogeneous in human CRC and in CRC cell lines. These results might have relevant implications for a better understanding of colorectal carcinogenesis.

Original languageEnglish
Pages (from-to)98-105
Number of pages8
JournalCancer Investigation
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Clock genes
  • Colorectal cancer
  • SIRT1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'SIRT1 and the clock gene machinery in colorectal cancer'. Together they form a unique fingerprint.

Cite this