Sirt1: Def-eating senescence?

Salvatore Fusco, Giuseppe Maulucci, Giovambattista Pani

Research output: Contribution to journalArticle

Abstract

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to "healthspan," and a decline of Sirt-centered protective circuits over time may explain the "catastrophic" nature of aging.

Original languageEnglish
Pages (from-to)4135-4146
Number of pages12
JournalCell Cycle
Volume11
Issue number22
DOIs
Publication statusPublished - Nov 15 2012

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Eating
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Fungal Proteins
Energy Metabolism
Enzymes
Research
Neoplasms

Keywords

  • Aging
  • Calorie restriction
  • CR
  • Metabolic disease
  • Nutrient signaling
  • Sirt1

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Fusco, S., Maulucci, G., & Pani, G. (2012). Sirt1: Def-eating senescence? Cell Cycle, 11(22), 4135-4146. https://doi.org/10.4161/cc.22074

Sirt1 : Def-eating senescence? / Fusco, Salvatore; Maulucci, Giuseppe; Pani, Giovambattista.

In: Cell Cycle, Vol. 11, No. 22, 15.11.2012, p. 4135-4146.

Research output: Contribution to journalArticle

Fusco, S, Maulucci, G & Pani, G 2012, 'Sirt1: Def-eating senescence?', Cell Cycle, vol. 11, no. 22, pp. 4135-4146. https://doi.org/10.4161/cc.22074
Fusco S, Maulucci G, Pani G. Sirt1: Def-eating senescence? Cell Cycle. 2012 Nov 15;11(22):4135-4146. https://doi.org/10.4161/cc.22074
Fusco, Salvatore ; Maulucci, Giuseppe ; Pani, Giovambattista. / Sirt1 : Def-eating senescence?. In: Cell Cycle. 2012 ; Vol. 11, No. 22. pp. 4135-4146.
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