SIRT1 signaling as potential modulator of skeletal muscle diseases

Joanne Tonkin, Francesc Villarroya, Pier Lorenzo Puri, Manlio Vinciguerra

Research output: Contribution to journalArticle

Abstract

Skeletal muscle diseases heavily impair the strength and the movement of patients. Muscles loose their adaptive capacity, undergoing atrophy or wasting, due to a number of pathological insults. Metabolic changes, such as those occurring during aging, contribute to the progressive reduction of myofiber size and decline of skeletal muscle performance that is typically observed in the elderly. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 has been involved in the protection against metabolic disorders, against cancers and in the enhancement of life span. Here we discuss the current evidence placing SIRT1 at the crossroad between energy homeostasis, fiber strength, and regeneration from damage in the skeletal muscle. Furthermore, we underline how cell type specific targeting of SIRT1 could be beneficial in the treatment of skeletal muscle diseases.

Original languageEnglish
Pages (from-to)372-376
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 2012

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ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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