Sister chromatid exchange induction in peripheral blood lymphocytes of traffic police workers

Claudia Bolognesi, Elena Gallerani, Stefania Bonatti, Marcella De Ferrari, Vincenzo Fontana, Federico Valerio, Franco Merlo, Angelo Abbondandolo

Research output: Contribution to journalArticlepeer-review

Abstract

Traffic police workers, as a population exposed to urban atmosphere, were compared with a control population exposed to indoor air pollution levels. Sister chromatid exchanges (SCEs) as a biomarker of effect were measured in peripheral blood lymphocytes of 54 exposed subjects and 35 controls, and environmental concentration of polynuclear aromatic hydrocarbon (PAH) tracer compounds was detected by personal air samplers. The mean exposure level to benzo[a]pyrene in our group of traffic policemen (3.4 mg/m3) was in the range that has been estimated in urban areas in Europe daring the last 10 years. No difference in SCE levels was found between exposed workers (7.36, SD 1.35) and controls (7.47, SD 1.28). No correlation was observed between SCE/cell and airborne PAH concentration in the traffic worker population. A positive regression of SCE on exposure estimate was found only in the non-smoking group of police workers. Our findings suggest that exposure to urban air pollution does not induce relevant cytogenetic effects.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume394
Issue number1-3
DOIs
Publication statusPublished - Nov 27 1997

Keywords

  • Cytogenetic biomonitoring
  • Sister chromatid exchange
  • Traffic policeman

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

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