Sister Joseph's nodule in a liver transplant recipient

Case report and mini-review of literature

Fabrizio Panaro, Enzo Andorno, Stefano Di Domenico, Nicola Morelli, Giuliano Bottino, Rosalia Mondello, Marco Miggino, Tomasz M. Jarzembowski, Ferruccio Ravazzoni, Marco Casaccia, Umberto Valente

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal. Conclusions: The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.

Original languageEnglish
JournalWorld Journal of Surgical Oncology
Volume3
DOIs
Publication statusPublished - Jan 14 2005

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Sister Mary Joseph's Nodule
Umbilicus
Liver
Papillary Cystadenocarcinoma
Serous Cystadenocarcinoma
Neoplasm Metastasis
Transplants
Drug Therapy
End Stage Liver Disease
Groin
Immunosuppressive Agents
Hepatitis C
Ultrasonography
Transplantation
Tissue Donors
Biopsy
Transplant Recipients
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Surgery

Cite this

Panaro, F., Andorno, E., Di Domenico, S., Morelli, N., Bottino, G., Mondello, R., ... Valente, U. (2005). Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature. World Journal of Surgical Oncology, 3. https://doi.org/10.1186/1477-7819-3-4

Sister Joseph's nodule in a liver transplant recipient : Case report and mini-review of literature. / Panaro, Fabrizio; Andorno, Enzo; Di Domenico, Stefano; Morelli, Nicola; Bottino, Giuliano; Mondello, Rosalia; Miggino, Marco; Jarzembowski, Tomasz M.; Ravazzoni, Ferruccio; Casaccia, Marco; Valente, Umberto.

In: World Journal of Surgical Oncology, Vol. 3, 14.01.2005.

Research output: Contribution to journalArticle

Panaro, F, Andorno, E, Di Domenico, S, Morelli, N, Bottino, G, Mondello, R, Miggino, M, Jarzembowski, TM, Ravazzoni, F, Casaccia, M & Valente, U 2005, 'Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature', World Journal of Surgical Oncology, vol. 3. https://doi.org/10.1186/1477-7819-3-4
Panaro, Fabrizio ; Andorno, Enzo ; Di Domenico, Stefano ; Morelli, Nicola ; Bottino, Giuliano ; Mondello, Rosalia ; Miggino, Marco ; Jarzembowski, Tomasz M. ; Ravazzoni, Ferruccio ; Casaccia, Marco ; Valente, Umberto. / Sister Joseph's nodule in a liver transplant recipient : Case report and mini-review of literature. In: World Journal of Surgical Oncology. 2005 ; Vol. 3.
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AU - Di Domenico, Stefano

AU - Morelli, Nicola

AU - Bottino, Giuliano

AU - Mondello, Rosalia

AU - Miggino, Marco

AU - Jarzembowski, Tomasz M.

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AU - Casaccia, Marco

AU - Valente, Umberto

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AB - Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal. Conclusions: The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.

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