Abstract
Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal. Conclusions: The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.
| Original language | English |
|---|---|
| Journal | World Journal of Surgical Oncology |
| Volume | 3 |
| DOIs | |
| Publication status | Published - Jan 14 2005 |
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ASJC Scopus subject areas
- Cancer Research
- Surgery
Cite this
Sister Joseph's nodule in a liver transplant recipient : Case report and mini-review of literature. / Panaro, Fabrizio; Andorno, Enzo; Di Domenico, Stefano; Morelli, Nicola; Bottino, Giuliano; Mondello, Rosalia; Miggino, Marco; Jarzembowski, Tomasz M.; Ravazzoni, Ferruccio; Casaccia, Marco; Valente, Umberto.
In: World Journal of Surgical Oncology, Vol. 3, 14.01.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sister Joseph's nodule in a liver transplant recipient
T2 - Case report and mini-review of literature
AU - Panaro, Fabrizio
AU - Andorno, Enzo
AU - Di Domenico, Stefano
AU - Morelli, Nicola
AU - Bottino, Giuliano
AU - Mondello, Rosalia
AU - Miggino, Marco
AU - Jarzembowski, Tomasz M.
AU - Ravazzoni, Ferruccio
AU - Casaccia, Marco
AU - Valente, Umberto
PY - 2005/1/14
Y1 - 2005/1/14
N2 - Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal. Conclusions: The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.
AB - Background: Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule. Case presentation: A 59-years-old Caucasian female underwent liver transplant for end stage liver disease due to hepatitis C with whole graft from cadaveric donor in 2003. After transplantation the patient developed multiple subcutaneous nodules in the umbilical region and bilateral inguinal lymphadenopathy. The excision biopsy of the umbilical mass showed the features of a poorly differentiated papillary serous cystadenocarcinoma. Computed tomographic scan and transvaginal ultrasonography were unable to demonstrate any primary lesion. Chemotherapy was start and the dosage of the immunosuppressive drugs was reduced. To date the patient is doing well and liver function is normal. Conclusions: The umbilical metastasis can arise from many sites. In some cases, primary tumor may be not identified; nonetheless chemotherapy must be administrated based on patient's history, anatomical and histological findings.
UR - http://www.scopus.com/inward/record.url?scp=13844255200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844255200&partnerID=8YFLogxK
U2 - 10.1186/1477-7819-3-4
DO - 10.1186/1477-7819-3-4
M3 - Article
VL - 3
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
SN - 1477-7819
ER -