Sister Mary Joseph's nodule in endometrial cancer: A case report and review of the literature

Martina De Angeli, Mariantonia Carosi, Enrico Vizza, Giacomo Corrado

Research output: Contribution to journalArticlepeer-review


Sister Mary Joseph's nodule (SMJN) is an umbilical mass referring to an intraabdominal and/or pelvic tumor's metastasis. SMJN is frequently associated with gynecological malignancies, but only 30 cases of SMJN originated from endometrial cancer have been described in the literature. We reported a case of SMJN detected within the primary diagnosis of endometrial cancer, in which a 1-year vaginal relapse occurs. A robotic single-site total hysterectomy and a bilateral salpingo-oophorectomy were performed to treat the primary tumor, followed by an adjuvant radiotherapy. The SMJN was resected during the surgical procedure. The relapse was treated by a partial colpectomy. No evidence of disease has been observed to date, and an overall survival of 31 months has been achieved. Due to the rare occurrence of an umbilical metastasis from an endometrial carcinoma, SMJN is difficult to recognize in this contest; nevertheless, its diagnosis is becoming increasingly important in relation to the choice of a proper treatment.

Original languageEnglish
Pages (from-to)1408-1410
Number of pages3
JournalJournal of Cancer Research and Therapeutics
Issue number6
Publication statusPublished - Oct 1 2019


  • Endometrial cancer
  • robotic surgery
  • umbilical metastasis

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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