TY - JOUR
T1 - Site-specific atherosclerotic plaques in the carotid arteries of middle-aged women from Southern Italy
T2 - Associations with traditional risk factors and oxidation markers
AU - Rubba, Paolo
AU - Panico, Salvatore
AU - Bond, M. Gene
AU - Covetti, Giuseppe
AU - Celentano, Egidio
AU - Iannuzzi, Arcangelo
AU - Galasso, Rocco
AU - Belisario, M. Antonietta
AU - Pastinese, Antonella
AU - Sacchetti, Lucia
AU - Mancini, Mario
AU - Salvatore, Francesco
PY - 2001
Y1 - 2001
N2 - Background and Purpose - Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in different carotid segments in relation to traditional (lipoprotein abnormalities, high blood pressure, cigarette smoking) and nontraditional (oxidation markers) cardiovascular risk factors. Methods - More than 5000 clinically healthy, middle-aged women (n=5062; age range, 30 to 69 years) living in the area of Naples in southern Italy participated in the Progetto Arena, a population-based study on the etiology of cardiovascular disease and cancer in the female population. A subsample of 310 participants underwent high-resolution B-mode ultrasound to assess intima-media thickness of common carotid artery and carotid bifurcation. Results - Early atherosclerotic plaques (intima-media thickness >1.2 mm) were detected within the common carotid arteries in 37 women, in the carotid bifurcations in 77 women, and in both sites in 91 women. After age adjustment, common carotid plaques were found to be associated with higher systolic blood pressure (143 versus 138 mm Hg; P2; P
AB - Background and Purpose - Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in different carotid segments in relation to traditional (lipoprotein abnormalities, high blood pressure, cigarette smoking) and nontraditional (oxidation markers) cardiovascular risk factors. Methods - More than 5000 clinically healthy, middle-aged women (n=5062; age range, 30 to 69 years) living in the area of Naples in southern Italy participated in the Progetto Arena, a population-based study on the etiology of cardiovascular disease and cancer in the female population. A subsample of 310 participants underwent high-resolution B-mode ultrasound to assess intima-media thickness of common carotid artery and carotid bifurcation. Results - Early atherosclerotic plaques (intima-media thickness >1.2 mm) were detected within the common carotid arteries in 37 women, in the carotid bifurcations in 77 women, and in both sites in 91 women. After age adjustment, common carotid plaques were found to be associated with higher systolic blood pressure (143 versus 138 mm Hg; P2; P
KW - Atherosclerosis
KW - Oxidized low density lipoprotein
KW - Risk factors
KW - Ultrasonics
KW - Women
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M3 - Article
C2 - 11546880
AN - SCOPUS:0034827872
VL - 32
SP - 1953
EP - 1959
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 9
ER -