Site-specific atherosclerotic plaques in the carotid arteries of middle-aged women from Southern Italy: Associations with traditional risk factors and oxidation markers

Paolo Rubba, Salvatore Panico, M. Gene Bond, Giuseppe Covetti, Egidio Celentano, Arcangelo Iannuzzi, Rocco Galasso, M. Antonietta Belisario, Antonella Pastinese, Lucia Sacchetti, Mario Mancini, Francesco Salvatore

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose - Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in different carotid segments in relation to traditional (lipoprotein abnormalities, high blood pressure, cigarette smoking) and nontraditional (oxidation markers) cardiovascular risk factors. Methods - More than 5000 clinically healthy, middle-aged women (n=5062; age range, 30 to 69 years) living in the area of Naples in southern Italy participated in the Progetto Arena, a population-based study on the etiology of cardiovascular disease and cancer in the female population. A subsample of 310 participants underwent high-resolution B-mode ultrasound to assess intima-media thickness of common carotid artery and carotid bifurcation. Results - Early atherosclerotic plaques (intima-media thickness >1.2 mm) were detected within the common carotid arteries in 37 women, in the carotid bifurcations in 77 women, and in both sites in 91 women. After age adjustment, common carotid plaques were found to be associated with higher systolic blood pressure (143 versus 138 mm Hg; P2; P

Original languageEnglish
Pages (from-to)1953-1959
Number of pages7
JournalStroke
Volume32
Issue number9
Publication statusPublished - 2001

Keywords

  • Atherosclerosis
  • Oxidized low density lipoprotein
  • Risk factors
  • Ultrasonics
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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