Sitilo Experience on Peritoneal Carcinomatosis from Colorectal Cancer: Clinical Prognostic Features

Francesco Cavaliere, P. Perri, C. R. Rossi, P. L. Pilati, M. De Simone, M. Vaira, M. Deraco, S. Aloe, S. Di Filippo, F. Di Filippo

Research output: Contribution to journalArticlepeer-review

Abstract

A multicentric prospective study has been carried on 69 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intraoperative hyperthermic chemoperfusion. CC 0-1 has been achieved in 82%. Major morbidity and mortality was 21.7% and 2.9% respectively. Three-yrs overall survival was 26.7% for all series. Difference in survival evaluating CC 0-1 vs. CC 2 pts and PCI ≤ 10 vs. > 10 was statistically significant. Evaluating only patients CC 0-1 and PCI ≤ 10 4-yrs overall survival rised up to 44.7%. A smaller subgroup of patients with a disease-free interval to peritoneal carcinomatosis ≥ 2-yrs showed a 5-yrs disease-free survival of 50%. Conclusions: PCI ≤ 10, complete or optimal cytoreduction feasibility have to be considered for the patients selection to the integrate treatment. Disease-free interval seems to be a powerful prognostic indicator and deserve to be better outlined in further studies.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalJournal of Experimental and Clinical Cancer Research
Volume22
Issue number4 SUPPL.
Publication statusPublished - Dec 2003

Keywords

  • Hyperthermic chemoperfusion
  • Peritoneal carcinomatosis
  • Peritonectomy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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