Abstract
Background-The six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) are the 2 testing modalities most broadly used for assessing functional limitation in patients with heart failure (HF). A comprehensive comparison on clinical and prognostic validity of the 2 techniques has not been performed and is the aim of the present investigation. Methods and Results-Two hundred fifty-three patients diagnosed with systolic (n=211) or diastolic (n=42) HF (age: 61.9± 10.1 years; New York Heart Association Class: 2.2±0.78) underwent a 6MWT and a symptom-limited CPET evaluation and were prospectively followed up. During the 4-year tracking period, there were 43 cardiac-related deaths with an annual cardiac mortality rate of 8.7%. The 6MWT distance correlated with CPET-derived variables (ie, peak Vo2, Vo2 at anaerobic threshold, and Ve/Vco2 slope) and was significantly reduced in proportion with lower peak Vo2 and higher Ve/Vco2 slope classes and presence of an exercise oscillatory breathing (EOB) pattern (P2 slope (entire population with HF and patients with a 6MWT≤300 m). Conclusions-The 6MWT is confirmed to be a simple and reliable first-line test for quantification of exercise intolerance in patients with HF. However, there is no supportive evidence for its use as a prognostic marker in alternative to or in conjunction with CPET-derived variables.
| Original language | English |
|---|---|
| Pages (from-to) | 549-555 |
| Number of pages | 7 |
| Journal | Circulation: Heart Failure |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 2009 |
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Keywords
- Exercise
- Heart failure
- Prognosis
- Ventilation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure : A comparative analysis on clinical and prognostic insights. / Guazzi, Marco; Dickstein, Kenneth; Vicenzi, Marco; Arena, Ross.
In: Circulation: Heart Failure, Vol. 2, No. 6, 11.2009, p. 549-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure
T2 - A comparative analysis on clinical and prognostic insights
AU - Guazzi, Marco
AU - Dickstein, Kenneth
AU - Vicenzi, Marco
AU - Arena, Ross
PY - 2009/11
Y1 - 2009/11
N2 - Background-The six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) are the 2 testing modalities most broadly used for assessing functional limitation in patients with heart failure (HF). A comprehensive comparison on clinical and prognostic validity of the 2 techniques has not been performed and is the aim of the present investigation. Methods and Results-Two hundred fifty-three patients diagnosed with systolic (n=211) or diastolic (n=42) HF (age: 61.9± 10.1 years; New York Heart Association Class: 2.2±0.78) underwent a 6MWT and a symptom-limited CPET evaluation and were prospectively followed up. During the 4-year tracking period, there were 43 cardiac-related deaths with an annual cardiac mortality rate of 8.7%. The 6MWT distance correlated with CPET-derived variables (ie, peak Vo2, Vo2 at anaerobic threshold, and Ve/Vco2 slope) and was significantly reduced in proportion with lower peak Vo2 and higher Ve/Vco2 slope classes and presence of an exercise oscillatory breathing (EOB) pattern (P2 slope (entire population with HF and patients with a 6MWT≤300 m). Conclusions-The 6MWT is confirmed to be a simple and reliable first-line test for quantification of exercise intolerance in patients with HF. However, there is no supportive evidence for its use as a prognostic marker in alternative to or in conjunction with CPET-derived variables.
AB - Background-The six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) are the 2 testing modalities most broadly used for assessing functional limitation in patients with heart failure (HF). A comprehensive comparison on clinical and prognostic validity of the 2 techniques has not been performed and is the aim of the present investigation. Methods and Results-Two hundred fifty-three patients diagnosed with systolic (n=211) or diastolic (n=42) HF (age: 61.9± 10.1 years; New York Heart Association Class: 2.2±0.78) underwent a 6MWT and a symptom-limited CPET evaluation and were prospectively followed up. During the 4-year tracking period, there were 43 cardiac-related deaths with an annual cardiac mortality rate of 8.7%. The 6MWT distance correlated with CPET-derived variables (ie, peak Vo2, Vo2 at anaerobic threshold, and Ve/Vco2 slope) and was significantly reduced in proportion with lower peak Vo2 and higher Ve/Vco2 slope classes and presence of an exercise oscillatory breathing (EOB) pattern (P2 slope (entire population with HF and patients with a 6MWT≤300 m). Conclusions-The 6MWT is confirmed to be a simple and reliable first-line test for quantification of exercise intolerance in patients with HF. However, there is no supportive evidence for its use as a prognostic marker in alternative to or in conjunction with CPET-derived variables.
KW - Exercise
KW - Heart failure
KW - Prognosis
KW - Ventilation
UR - http://www.scopus.com/inward/record.url?scp=77953680227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953680227&partnerID=8YFLogxK
U2 - 10.1161/CIRCHEARTFAILURE.109.881326
DO - 10.1161/CIRCHEARTFAILURE.109.881326
M3 - Article
C2 - 19919979
AN - SCOPUS:77953680227
VL - 2
SP - 549
EP - 555
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
SN - 1941-3297
IS - 6
ER -