The aim of our longitudinal multicentric study was to establish the changes on the 6. min walk test (6MWT) in ambulant SMA type III children and adults over a 12. month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12. months after baseline. The distance covered in 6. min ranged between 75 and 510. m (mean 294.91, SD 127) at baseline and between 50 and 611. m (mean 293.41. m, SD 141) at 12. months. The mean change in distance between baseline and 12. months was -1.46 (SD 50.1; range: -183 to 131.8. m). The changes were not correlated with age or baseline values (p> .05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30. m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients.
- Outcome measures
- Spinal muscular atrophy
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health