Six-minute walking distance improvement after pulmonary rehabilitation is associated with baseline lung function in complex COPD patients: A retrospective study

Andrea Zanini, Alfredo Chetta, Federico Gumiero, Sabrina Della Patrona, Silvia Casale, Elisabetta Zampogna, Marina Aiello, Antonio Spanevello

Research output: Contribution to journalArticle

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Abstract

Introduction. Conflicting results have been so far reported about baseline lung function, as predicting factor of pulmonary rehabilitation (PR) efficacy. Aim. To ascertain whether or not baseline lung function could predict a benefit in terms of a significant change in 6-min walk test (6MWT) after PR. Methods. Seventy-five stable moderate-to-severe COPD inpatients with comorbidities (complex COPD), allocated to a three-week PR program, were retrospectively evaluated. Pulmonary function, 6MWT, dyspnea (BDI/TDI), and quality of life (EQ-VAS) were assessed before and after PR program. The patients were divided into two groups depending on the change in 6MWT (responders > 30 m and nonresponders ≤ 30 m). Logistic regression analysis was used. Results. After PR, 6MWT performance all outcome measures significantly improved (P <0.01). Compared to nonresponders (N = 38), the responders (N = 37) had lower values in baseline lung function (P <0.01). Logistic regression analysis showed that FEV<50% pred and TL, CO <50% pred were independent predictors of PR efficacy. Conclusions. Our study shows that in stable moderate-to-severe complex COPD inpatients, baseline lung function may predict the response to PR in terms of 6MWT. We also found that complex COPD patients with poor lung function get more benefit from PR.

Original languageEnglish
Article number483162
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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Patient rehabilitation
Chronic Obstructive Pulmonary Disease
Walking
Rehabilitation
Retrospective Studies
Lung
Regression analysis
Logistics
Carbon Monoxide
Inpatients
Logistic Models
Regression Analysis
Dyspnea
Comorbidity
Quality of Life
Outcome Assessment (Health Care)
Walk Test

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Six-minute walking distance improvement after pulmonary rehabilitation is associated with baseline lung function in complex COPD patients : A retrospective study. / Zanini, Andrea; Chetta, Alfredo; Gumiero, Federico; Della Patrona, Sabrina; Casale, Silvia; Zampogna, Elisabetta; Aiello, Marina; Spanevello, Antonio.

In: BioMed Research International, Vol. 2013, 483162, 2013.

Research output: Contribution to journalArticle

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abstract = "Introduction. Conflicting results have been so far reported about baseline lung function, as predicting factor of pulmonary rehabilitation (PR) efficacy. Aim. To ascertain whether or not baseline lung function could predict a benefit in terms of a significant change in 6-min walk test (6MWT) after PR. Methods. Seventy-five stable moderate-to-severe COPD inpatients with comorbidities (complex COPD), allocated to a three-week PR program, were retrospectively evaluated. Pulmonary function, 6MWT, dyspnea (BDI/TDI), and quality of life (EQ-VAS) were assessed before and after PR program. The patients were divided into two groups depending on the change in 6MWT (responders > 30 m and nonresponders ≤ 30 m). Logistic regression analysis was used. Results. After PR, 6MWT performance all outcome measures significantly improved (P <0.01). Compared to nonresponders (N = 38), the responders (N = 37) had lower values in baseline lung function (P <0.01). Logistic regression analysis showed that FEV<50{\%} pred and TL, CO <50{\%} pred were independent predictors of PR efficacy. Conclusions. Our study shows that in stable moderate-to-severe complex COPD inpatients, baseline lung function may predict the response to PR in terms of 6MWT. We also found that complex COPD patients with poor lung function get more benefit from PR.",
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AU - Zanini, Andrea

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AU - Della Patrona, Sabrina

AU - Casale, Silvia

AU - Zampogna, Elisabetta

AU - Aiello, Marina

AU - Spanevello, Antonio

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N2 - Introduction. Conflicting results have been so far reported about baseline lung function, as predicting factor of pulmonary rehabilitation (PR) efficacy. Aim. To ascertain whether or not baseline lung function could predict a benefit in terms of a significant change in 6-min walk test (6MWT) after PR. Methods. Seventy-five stable moderate-to-severe COPD inpatients with comorbidities (complex COPD), allocated to a three-week PR program, were retrospectively evaluated. Pulmonary function, 6MWT, dyspnea (BDI/TDI), and quality of life (EQ-VAS) were assessed before and after PR program. The patients were divided into two groups depending on the change in 6MWT (responders > 30 m and nonresponders ≤ 30 m). Logistic regression analysis was used. Results. After PR, 6MWT performance all outcome measures significantly improved (P <0.01). Compared to nonresponders (N = 38), the responders (N = 37) had lower values in baseline lung function (P <0.01). Logistic regression analysis showed that FEV<50% pred and TL, CO <50% pred were independent predictors of PR efficacy. Conclusions. Our study shows that in stable moderate-to-severe complex COPD inpatients, baseline lung function may predict the response to PR in terms of 6MWT. We also found that complex COPD patients with poor lung function get more benefit from PR.

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