Six-month and one-year clinical outcomes after placement of a dedicated coronary bifurcation stent: A patient-level pooled analysis of eight registry studies

Maik J. Grundeken, Solomon Asgedom, Peter Damman, Maciej Lesiak, Michael S. Norell, Eulogio Garcia, Armando Bethencourt, Pier Woudstra, Karel T. Koch, Marije M. Vis, Jose P S Henriques, Yoshinobu Onuma, David P. Foley, Antonio L. Bartorelli, Pieter R. Stella, Jan G P Tijssen, Robbert J. De Winter, Joanna J. Wykrzykowska

Research output: Contribution to journalArticle

Abstract

Aims: Smaller studies have previously shown promising results after Tryton Side Branch Stent™ (Tryton Medical, Durham, NC, USA) placement. However, these previous studies were limited by their small sample size and relatively short follow-up. We performed a patient-level pooled analysis to evaluate six-month and one-year clinical outcomes of more than 900 patients who were enrolled in eight registries with the Tryton stent. Methods and results: Data from eight Tryton registries, including 905 patients with 929 bifurcation lesions, were pooled on a patient level to form one dataset. The primary outcome was six-month target vessel failure (TVF), defined as the composite of cardiac death, any myocardial infarction, and clinically indicated target vessel revascularisation. Procedural success was defined as successful stent placement and no in-hospital major adverse cardiac events. Multivariable analysis was performed to determine independent predictors for one-year TVF. Follow-up data were available in 97%. Procedural success was 95% and TVF rate was 6.5% at six months and 8.5% at one year. Stent thrombosis occurred in 0.5% of patients. Left main coronary artery bifurcation lesion (HR 6.46) and main branch reference vessel diameter

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalEuroIntervention
Volume9
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Coronary artery disease
  • Coronary bifurcation lesion
  • Dedicated bifurcation stent
  • Tryton side branch stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Grundeken, M. J., Asgedom, S., Damman, P., Lesiak, M., Norell, M. S., Garcia, E., Bethencourt, A., Woudstra, P., Koch, K. T., Vis, M. M., Henriques, J. P. S., Onuma, Y., Foley, D. P., Bartorelli, A. L., Stella, P. R., Tijssen, J. G. P., De Winter, R. J., & Wykrzykowska, J. J. (2013). Six-month and one-year clinical outcomes after placement of a dedicated coronary bifurcation stent: A patient-level pooled analysis of eight registry studies. EuroIntervention, 9(2), 195-203. https://doi.org/10.4244/EIJV9I2A34