Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure

Marco Guazzi, Ross Arena, Sherry Pinkstaff, Maurizio D. Guazzi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Previous research has demonstrated an increase in large vessel stiffness in patients with heart failure (HF). Furthermore, heart rate recovery (HRR) may be negatively impacted by increased arterial stiffness secondary to altered baroreceptor discharge. The purpose of the present study was to determine if chronic phosphodiesterase 5 (PDE5) inhibition with Sildenafil, previously shown to improve arterial stiffness, favorably impacts HRR in patients with HF. Forty male subjects (age: 65.3 ± 7.3 years, baseline ejection fraction: 37.1 ± 7.4%, 15 non-ischemic HF/25 ischemic HF) participated in this study. Subjects received Sildenafil (25 mg, 3 times/day) for six months. Symptom-limited exercise testing was performed at baseline and six months with a lower extremity ergometer. Heart rate recovery was defined as HR at maximal exercise minus HR at 1 min recovery. No adverse effects were reported throughout the study period. Paired t-testing revealed that HRR was significantly improved following six months of Sildenafil therapy (baseline: 17.5 ± 3.5 bpm vs. Post: 20.6 ± 3.2 bpm). The results of the present study indicate that chronic Sildenafil therapy significantly increases HRR, an important prognostic marker, in patients with HF. A plausible mechanism for the improvement of HRR is the previously demonstrated impact Sildenafil has on arterial stiffness and therefore baroreceptor function.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalInternational Journal of Cardiology
Volume136
Issue number3
DOIs
Publication statusPublished - Aug 21 2009

Fingerprint

Heart Failure
Heart Rate
Vascular Stiffness
Pressoreceptors
Therapeutics
Exercise
Type 5 Cyclic Nucleotide Phosphodiesterases
Sildenafil Citrate
Lower Extremity
Research

Keywords

  • Arterial stiffness
  • Autonomic tone
  • Baroreceptor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure. / Guazzi, Marco; Arena, Ross; Pinkstaff, Sherry; Guazzi, Maurizio D.

In: International Journal of Cardiology, Vol. 136, No. 3, 21.08.2009, p. 341-343.

Research output: Contribution to journalArticle

Guazzi, Marco ; Arena, Ross ; Pinkstaff, Sherry ; Guazzi, Maurizio D. / Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure. In: International Journal of Cardiology. 2009 ; Vol. 136, No. 3. pp. 341-343.
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