SJS/TEN overlap associated with lomefloxacin: Case report and molecular typing studies

Davide Lonati, Arturo Zancan, Annamaria Pasi, Annia Schreiber, Andrea Giampreti, Patrizia Pignatti, Maurizio Stella, Carlo Alessandro Locatelli, Luigi Manzo, Miryam Martinetti

Research output: Contribution to journalArticle

Abstract

Background: Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) may develop in susceptible patients after administration of different drugs. Only mild cutaneous reactions have been related to lomefloxacin. A correlation between human leucocyte antigen (HLA) and cutaneous adverse reaction has been identified. Case Report: Twenty-four hours after intake of lomefloxacin, a 30-year-old Caucasian woman developed a severe skin reaction with symptoms suggesting SJS/TEN. The fast onset reaction worsened with skin blisters and 20% body surface area skin detachment within 48 h. Burn unit admittance was required; corticosteroids and human immunoglobulins were administered. Complete recovery occurred within 3 months, except for epidermal discoloration. Molecular studies showed a peculiar profile characterized by HLA class I genotype rich of ligands for natural killer cell immunoglobulin-like receptors (KIR) and HLA class II haplotype, HLA-DRB1∗03:01,DQB1∗02:01, prone to autoimmunity. Conclusion: While the HLA profile approaches our case to other well-documented drug-induced SJS/TEN, KIR involvement still remains puzzling.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalDermatology
Volume229
Issue number4
DOIs
Publication statusPublished - May 22 2014

Keywords

  • Cutaneous adverse reaction
  • Human leucocyte antigen
  • Killer cell immunoglobulin-like receptor
  • Quinolones
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

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