Skeletal muscle characteristics and motor performance after 2-year growth hormone treatment in adults with prader-willi syndrome

Claudio L. Lafortuna, Alessandro Minocci, Paolo Capodaglio, Luca A. Gondoni, Alessandro Sartorio, Luca Vismara, Giovanna Rizzo, Graziano Grugni

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Context: In adults with Prader-Willi syndrome (PWS), abnormal body composition with decreased lean body mass and skeletal muscle (SM) volume has been related to altered GH secretion and may possibly contribute to greatly reduced motor capacity. Objective: The scope of the studywasto test the hypothesis thatGHtreatment has favorable effects on SM characteristics and motor performance in adults with PWS. Design, Setting, and Participants: Fifteen obese PWS subjects (nine males and six females; age range, 19-35 y; body mass index, 37.7-59.9 kg/m2) were investigated before and after 12 (GH12) and 24 (GH24) months of GH treatment. Main Outcome Measures: SM cross-sectional area and SM attenuation were determined with computed tomography at the lumbar and midthigh levels. Maximal isometric handgrip strength and isokinetic knee extension peak torque were measured. Motor performance was evaluated with different indoor walking tests, whereas exercise endurance was assessed with a treadmill incremental test to exhaustion. Results: A condition of severe GH deficiency was found in six patients (40%). GH treatment significantly increased lean body mass (GH12, P <.05; GH24, P <.05), reduced percentage of body fat (GH12, P <.05; GH24, P <.05), and augmented SM cross-sectional area and SM attenuation of both lumbar (GH12, P

Original languageEnglish
Pages (from-to)1816-1824
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number5
DOIs
Publication statusPublished - 2014

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Prader-Willi Syndrome
Growth Hormone
Muscle
Skeletal Muscle
Exercise Test
Therapeutics
Exercise equipment
Torque
Body Composition
Walking
Tomography
Adipose Tissue
Knee
Durability
Body Mass Index
Fats
Outcome Assessment (Health Care)
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Skeletal muscle characteristics and motor performance after 2-year growth hormone treatment in adults with prader-willi syndrome. / Lafortuna, Claudio L.; Minocci, Alessandro; Capodaglio, Paolo; Gondoni, Luca A.; Sartorio, Alessandro; Vismara, Luca; Rizzo, Giovanna; Grugni, Graziano.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 5, 2014, p. 1816-1824.

Research output: Contribution to journalArticle

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