Abstract
Context: In adults with Prader-Willi syndrome (PWS), abnormal body composition with decreased lean body mass and skeletal muscle (SM) volume has been related to altered GH secretion and may possibly contribute to greatly reduced motor capacity. Objective: The scope of the studywasto test the hypothesis thatGHtreatment has favorable effects on SM characteristics and motor performance in adults with PWS. Design, Setting, and Participants: Fifteen obese PWS subjects (nine males and six females; age range, 19-35 y; body mass index, 37.7-59.9 kg/m2) were investigated before and after 12 (GH12) and 24 (GH24) months of GH treatment. Main Outcome Measures: SM cross-sectional area and SM attenuation were determined with computed tomography at the lumbar and midthigh levels. Maximal isometric handgrip strength and isokinetic knee extension peak torque were measured. Motor performance was evaluated with different indoor walking tests, whereas exercise endurance was assessed with a treadmill incremental test to exhaustion. Results: A condition of severe GH deficiency was found in six patients (40%). GH treatment significantly increased lean body mass (GH12, P <.05; GH24, P <.05), reduced percentage of body fat (GH12, P <.05; GH24, P <.05), and augmented SM cross-sectional area and SM attenuation of both lumbar (GH12, P
| Original language | English |
|---|---|
| Pages (from-to) | 1816-1824 |
| Number of pages | 9 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 99 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
Cite this
Skeletal muscle characteristics and motor performance after 2-year growth hormone treatment in adults with prader-willi syndrome. / Lafortuna, Claudio L.; Minocci, Alessandro; Capodaglio, Paolo; Gondoni, Luca A.; Sartorio, Alessandro; Vismara, Luca; Rizzo, Giovanna; Grugni, Graziano.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 5, 2014, p. 1816-1824.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Skeletal muscle characteristics and motor performance after 2-year growth hormone treatment in adults with prader-willi syndrome
AU - Lafortuna, Claudio L.
AU - Minocci, Alessandro
AU - Capodaglio, Paolo
AU - Gondoni, Luca A.
AU - Sartorio, Alessandro
AU - Vismara, Luca
AU - Rizzo, Giovanna
AU - Grugni, Graziano
PY - 2014
Y1 - 2014
N2 - Context: In adults with Prader-Willi syndrome (PWS), abnormal body composition with decreased lean body mass and skeletal muscle (SM) volume has been related to altered GH secretion and may possibly contribute to greatly reduced motor capacity. Objective: The scope of the studywasto test the hypothesis thatGHtreatment has favorable effects on SM characteristics and motor performance in adults with PWS. Design, Setting, and Participants: Fifteen obese PWS subjects (nine males and six females; age range, 19-35 y; body mass index, 37.7-59.9 kg/m2) were investigated before and after 12 (GH12) and 24 (GH24) months of GH treatment. Main Outcome Measures: SM cross-sectional area and SM attenuation were determined with computed tomography at the lumbar and midthigh levels. Maximal isometric handgrip strength and isokinetic knee extension peak torque were measured. Motor performance was evaluated with different indoor walking tests, whereas exercise endurance was assessed with a treadmill incremental test to exhaustion. Results: A condition of severe GH deficiency was found in six patients (40%). GH treatment significantly increased lean body mass (GH12, P <.05; GH24, P <.05), reduced percentage of body fat (GH12, P <.05; GH24, P <.05), and augmented SM cross-sectional area and SM attenuation of both lumbar (GH12, P
AB - Context: In adults with Prader-Willi syndrome (PWS), abnormal body composition with decreased lean body mass and skeletal muscle (SM) volume has been related to altered GH secretion and may possibly contribute to greatly reduced motor capacity. Objective: The scope of the studywasto test the hypothesis thatGHtreatment has favorable effects on SM characteristics and motor performance in adults with PWS. Design, Setting, and Participants: Fifteen obese PWS subjects (nine males and six females; age range, 19-35 y; body mass index, 37.7-59.9 kg/m2) were investigated before and after 12 (GH12) and 24 (GH24) months of GH treatment. Main Outcome Measures: SM cross-sectional area and SM attenuation were determined with computed tomography at the lumbar and midthigh levels. Maximal isometric handgrip strength and isokinetic knee extension peak torque were measured. Motor performance was evaluated with different indoor walking tests, whereas exercise endurance was assessed with a treadmill incremental test to exhaustion. Results: A condition of severe GH deficiency was found in six patients (40%). GH treatment significantly increased lean body mass (GH12, P <.05; GH24, P <.05), reduced percentage of body fat (GH12, P <.05; GH24, P <.05), and augmented SM cross-sectional area and SM attenuation of both lumbar (GH12, P
UR - http://www.scopus.com/inward/record.url?scp=84899972651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899972651&partnerID=8YFLogxK
U2 - 10.1210/jc.2013-3607
DO - 10.1210/jc.2013-3607
M3 - Article
C2 - 24471571
AN - SCOPUS:84899972651
VL - 99
SP - 1816
EP - 1824
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 5
ER -