Skeletal muscle is a primary site of insulin resistance in essential hypertension

B. Capaldo, G. Lembo, R. Napoli, V. Rendina, G. Albano, L. Saccà, B. Trimarco

Research output: Contribution to journalArticle

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Abstract

To determine the contribution of skeletal muscle to the insulin resistance of essential hypertension, insulin-stimulated forearm glucose uptake was quantitated in 12 control (age, 32 ± 3 years) and 12 hypertensive subjects (age, 36 ± 2 years) using the forearm perfusion technique. Peripheral insulin levels were raised acutely (∼ 60 μU/mL), while blood glucose concentration was clamped at its basal value (90 mg/dL) by a variable glucose infusion. During insulin stimulation, whole body glucose uptake was lower in hypertensive (4.5 ± .3 mg · kg-1 · min-1) than in normal subjects (5.8 ± .4 mg · kg-1 · min-1, P <.05). Similarly, the amount of glucose taken up by the forearm was markedly reduced in the hypertensive (5.3 ± .91 mg · L-1 · min-1) compared with the control group (8.7 ± 1.1 mg · L-1 · min-1). No appreciable difference was observed as to forearm blood flow (39 ± 4 mL · L-1 · min-1 and 37 ± 5 mL · L-1 · min-1) in hypertensive patients. These results indicate that skeletal muscle is a major site of insulin resistance in essential hypertension and that this defect is independent of muscle perfusion.

Original languageEnglish
Pages (from-to)1320-1322
Number of pages3
JournalMetabolism
Volume40
Issue number12
DOIs
Publication statusPublished - 1991

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Forearm
Insulin Resistance
Skeletal Muscle
Glucose
Insulin
Perfusion
Blood Glucose
Muscles
Control Groups
Essential Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Capaldo, B., Lembo, G., Napoli, R., Rendina, V., Albano, G., Saccà, L., & Trimarco, B. (1991). Skeletal muscle is a primary site of insulin resistance in essential hypertension. Metabolism, 40(12), 1320-1322. https://doi.org/10.1016/0026-0495(91)90036-V

Skeletal muscle is a primary site of insulin resistance in essential hypertension. / Capaldo, B.; Lembo, G.; Napoli, R.; Rendina, V.; Albano, G.; Saccà, L.; Trimarco, B.

In: Metabolism, Vol. 40, No. 12, 1991, p. 1320-1322.

Research output: Contribution to journalArticle

Capaldo, B, Lembo, G, Napoli, R, Rendina, V, Albano, G, Saccà, L & Trimarco, B 1991, 'Skeletal muscle is a primary site of insulin resistance in essential hypertension', Metabolism, vol. 40, no. 12, pp. 1320-1322. https://doi.org/10.1016/0026-0495(91)90036-V
Capaldo, B. ; Lembo, G. ; Napoli, R. ; Rendina, V. ; Albano, G. ; Saccà, L. ; Trimarco, B. / Skeletal muscle is a primary site of insulin resistance in essential hypertension. In: Metabolism. 1991 ; Vol. 40, No. 12. pp. 1320-1322.
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