Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction

Research output: Contribution to journalReview article

Abstract

PURPOSE OF REVIEW: This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.

RECENT FINDINGS: The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF. The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.

Original languageEnglish
Pages (from-to)116
JournalCurrent Cardiology Reports
Volume20
Issue number11
DOIs
Publication statusPublished - Sep 26 2018

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Muscular Diseases
Skeletal Muscle
Heart Failure
Phenotype
Thoracic Surgery
Heart Ventricles
Hemodynamics
Exercise
Transplants

Cite this

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title = "Skeletal Muscle Myopathy in Heart Failure: the Role of Ejection Fraction",
abstract = "PURPOSE OF REVIEW: This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.RECENT FINDINGS: The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF. The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.",
author = "Mara Paneroni and Evasio Pasini and Laura Comini and Michele Vitacca and Federico Schena and Simonetta Scalvini and Massimo Venturelli",
year = "2018",
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day = "26",
doi = "10.1007/s11886-018-1056-x",
language = "English",
volume = "20",
pages = "116",
journal = "Current Cardiology Reports",
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TY - JOUR

T1 - Skeletal Muscle Myopathy in Heart Failure

T2 - the Role of Ejection Fraction

AU - Paneroni, Mara

AU - Pasini, Evasio

AU - Comini, Laura

AU - Vitacca, Michele

AU - Schena, Federico

AU - Scalvini, Simonetta

AU - Venturelli, Massimo

PY - 2018/9/26

Y1 - 2018/9/26

N2 - PURPOSE OF REVIEW: This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.RECENT FINDINGS: The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF. The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.

AB - PURPOSE OF REVIEW: This review summarizes: (1) the structural and functional features coupled with pathophysiological factors responsible of skeletal muscle myopathy (SMM) in both heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and (2) the role of exercise as treatment of SMM in these HF-related phenotypes.RECENT FINDINGS: The recent literature showed two main phenotypes of heart failure (HF): (1) HFrEF primarily due to a systolic dysfunction of the left ventricle and (2) HFpEF, mainly related to a diastolic dysfunction. Exercise intolerance is one of most disabling symptoms of HF and it is shown that persists after the normalization of the central hemodynamic impairments by therapy and/or cardiac surgery including heart transplant. A specific skeletal muscle myopathy (SMM) has been defined as one of the main causes of exercise intolerance in HF. The SMM has been well described in the last 20 years in the HFrEF; on the contrary, few studies are available in HFpEF. Recent evidences have revealed that exercise training counteracts HF-related SMM and in turn ameliorates exercise intolerance.

U2 - 10.1007/s11886-018-1056-x

DO - 10.1007/s11886-018-1056-x

M3 - Review article

C2 - 30259199

VL - 20

SP - 116

JO - Current Cardiology Reports

JF - Current Cardiology Reports

SN - 1523-3782

IS - 11

ER -