Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol

C. Santori, M. Ceccanti, D. Diacinti, M. L. Attilia, L. Toppo, E. D'Erasmo, E. Romagnoli, M. L. Mascia, C. Cipriani, A. Prastaro, V. Carnevale, Salvatore Minisola

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: Chronic alcohol abuse is a risk factor for osteoporosis and fractures, whose pathogenesis is still unclear. We investigated the influence of alcoholism and other risk factors on calcium and skeletal metabolism, bone mineral density (BMD), and fractures. Materials and methods: In 51 chronic male alcoholics without liver failure and 31 healthy controls, serum total and ionised calcium, phosphate, creatinine, 25-hydroxy vitamin D (250HD), PTH, total (ALP) and bone-specific (BALP) alkaline phosphatase, osteocalcin (BGP), carboxy-terminal telopeptide of type I collagen (β-CTx), osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) were assessed. In patients only, we also measured serum testosterone, 17-β estradiol, LH, and IGF-I. BMD was measured by dual energy x-ray absorptiometry at lumbar spine (LS-) and femur [neck (FN-) and total hip (TF-)]. Vertebral fractures were identified by a semi-quantitative method on thoraco-lumbar spine x-ray, non-vertebral fractures (as life-style factors) by history. Results: Alcoholics were leaner, had significantly higher ALP and BALP, and lower BGP and 25OHD levels than controls. No significant difference in other calcium and bone metabolism parameters was found. OPG/RANKL ratio was significantly higher in alcoholics. Beta-CTx negatively correlated with abuse duration. OPG positively correlated with daily alcohol assumption and with indexes of liver cytolysis. Though LS-, FN-and TF-BMD of alcoholics and controls did not significantly differ, patients had a much higher prevalence of vertebral fractures. The same was found considering both vertebral and non-vertebral fractures. Conclusions: Ethanol-induced skeletal damage seems mainly dependent on negative effects on bone formation. Lifestyle factors and traumas likely contribute to the high fracture incidence of alcohol abusers, independently of BMD.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalJournal of Endocrinological Investigation
Volume31
Issue number4
Publication statusPublished - Apr 2008

Fingerprint

Bone Fractures
Alcoholics
Osteoprotegerin
Bone Density
Alcohols
RANK Ligand
Spine
Alcoholism
Life Style
X-Rays
Calcium
Bone and Bones
Femur Neck
Osteocalcin
Liver Failure
Collagen Type I
Serum
Insulin-Like Growth Factor I
Osteogenesis
Vitamin D

Keywords

  • Bone mineral density
  • Fractures
  • Male alcohol abusers

ASJC Scopus subject areas

  • Endocrinology

Cite this

Santori, C., Ceccanti, M., Diacinti, D., Attilia, M. L., Toppo, L., D'Erasmo, E., ... Minisola, S. (2008). Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. Journal of Endocrinological Investigation, 31(4), 321-326.

Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. / Santori, C.; Ceccanti, M.; Diacinti, D.; Attilia, M. L.; Toppo, L.; D'Erasmo, E.; Romagnoli, E.; Mascia, M. L.; Cipriani, C.; Prastaro, A.; Carnevale, V.; Minisola, Salvatore.

In: Journal of Endocrinological Investigation, Vol. 31, No. 4, 04.2008, p. 321-326.

Research output: Contribution to journalArticle

Santori, C, Ceccanti, M, Diacinti, D, Attilia, ML, Toppo, L, D'Erasmo, E, Romagnoli, E, Mascia, ML, Cipriani, C, Prastaro, A, Carnevale, V & Minisola, S 2008, 'Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol', Journal of Endocrinological Investigation, vol. 31, no. 4, pp. 321-326.
Santori C, Ceccanti M, Diacinti D, Attilia ML, Toppo L, D'Erasmo E et al. Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. Journal of Endocrinological Investigation. 2008 Apr;31(4):321-326.
Santori, C. ; Ceccanti, M. ; Diacinti, D. ; Attilia, M. L. ; Toppo, L. ; D'Erasmo, E. ; Romagnoli, E. ; Mascia, M. L. ; Cipriani, C. ; Prastaro, A. ; Carnevale, V. ; Minisola, Salvatore. / Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. In: Journal of Endocrinological Investigation. 2008 ; Vol. 31, No. 4. pp. 321-326.
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AU - Toppo, L.

AU - D'Erasmo, E.

AU - Romagnoli, E.

AU - Mascia, M. L.

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