Skin cancer prevention in subjects affected by idiopathic photodermatoses treated with Polypodium leucotomos extract

Massimo Caccialanza, Roberta Piccinno, Diego Tosi, Serena Percivalle

Research output: Contribution to journalArticle

Abstract

The improvement of preventive devices against the development of skin neoplasms, which are constantly increasing, has a great practical interest. With this point of view the preventive measures against sunlight exposure damage fit in. Subjects affected by idiopathic photodermatoses have, as is known, an increased risk of photo-damage and photo-induced skin cancers. We treated 48 patients affected by idiopathic photodermatoses, non-responsive to the usual treatments, with an oral extract of Polypodium leucotomos, a fern native of Central America, with antioxidant, anti-inflammatory and immuno-modulating role, which has already been demonstrated effective in an animal model to reduce the development of epithelial neoplasms. Oral administration of Polypodium leucotomos resulted effective (p <0.05) in 81.24% of patients exposed to sunlight, reducing or nullifying skin lesions and symptoms occurred previously during sunlight exposure. No side effects were observed with this treatment.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalSkin Cancer
Volume23
Issue number2
Publication statusPublished - Apr 2008

Keywords

  • Idiopathic photodermatoses
  • Polypodium leucotomos
  • Skin cancer
  • Skin cancer prevention

ASJC Scopus subject areas

  • Dermatology
  • Oncology

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