Infanzia e fattori di rischio per tumori della cute: risultati di un indagine in aree italiane a diversa incidenza di melanoma cutaneo.

Translated title of the contribution: [Skin cancer risk factors in childhood: findings of a survey conducted within Italian areas with a different incidence of melanoma].

Valerio Ramazzotti, Maria Cecilia Cercato, Irene Terrenato, Pieluigi Santi, Fabio Falcini, Giorgio Assennato, Elena Gattei, Caterina Catricalà, Pier Giorgio Natali

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

to evaluate the association between phenotype and sun sensitivity factors, sun protection behavior, ethnicity and the area of residence in school-aged children. a cross-sectional study in the framework of a survey of children using a self-administered questionnaire to be filled in by parents. 56390 children attending primary schools located in the Italian provinces of Brindisi, Rome, Forlì and Genova, in the period between 1998-2002. Odds Ratios (ORs) and their relative 95% Confidence Intervals (95% CI) are to be computed through univariate and multivariate logistic regression models. "FOTO positive" phenotype, a proxy variable of the fair phenotype, was directly and significantly associated with the tendency to sunburn (OR 4.75; 95% CI 4.54-4.96), the use of sunscreens (OR 1.79; 95% CI 1.63-1.97), the number of grandparents born in the northern areas (OR 1.63; 95% CI 1.45-1.83, for four northern grandparents versus none), the presence of freckles on the face (OR 1.62; 95% CI 1.53-1.72) and of naevi on the left forearm (OR 1.20; 95% CI 1.15-1.26). A positive association was also found for the residence in the northern areas using the area of Brindisi as the reference category, (Rome: OR 1.02; 95% CI 0.95-1.10; Forlì: OR 1.05; 95% CI 0.96-1.15; Genova: OR 1.16; 95% CI 1.08-1.26); the ORs increase with latitude, as does the incidence rate of melanoma in Italy. An inverse association was observed with the male sex (OR 0.92; 95% CI 0.88-0.96), the increase of school-class level (OR 0.65; 95% CI 0.60-0.69, for the highest versus the lowest school-class level) and the ability to tan (OR 0.40; 95% CI 0.36-0.43). these findings confirmed that the fairness phenotype is associated with other skin cancer risk factors in children and pointed out that the high-risk phenotype has a geographical distribution consistent with the pattern of melanoma incidence in the Italian areas covered by the study.

Original languageItalian
Pages (from-to)82-88
Number of pages7
JournalEpidemiologia e prevenzione
Volume35
Issue number2
Publication statusPublished - Mar 2011

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Skin Neoplasms
Melanoma
Odds Ratio
Confidence Intervals
Incidence
Phenotype
Surveys and Questionnaires
Sun Protection Factor
Logistic Models
Sunburn
Melanosis
Sunscreening Agents
Aptitude
Nevus
Sex Ratio
Proxy
Solar System
Forearm
Italy
Cross-Sectional Studies

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Infanzia e fattori di rischio per tumori della cute : risultati di un indagine in aree italiane a diversa incidenza di melanoma cutaneo. / Ramazzotti, Valerio; Cercato, Maria Cecilia; Terrenato, Irene; Santi, Pieluigi; Falcini, Fabio; Assennato, Giorgio; Gattei, Elena; Catricalà, Caterina; Natali, Pier Giorgio.

In: Epidemiologia e prevenzione, Vol. 35, No. 2, 03.2011, p. 82-88.

Research output: Contribution to journalArticle

Ramazzotti, Valerio ; Cercato, Maria Cecilia ; Terrenato, Irene ; Santi, Pieluigi ; Falcini, Fabio ; Assennato, Giorgio ; Gattei, Elena ; Catricalà, Caterina ; Natali, Pier Giorgio. / Infanzia e fattori di rischio per tumori della cute : risultati di un indagine in aree italiane a diversa incidenza di melanoma cutaneo. In: Epidemiologia e prevenzione. 2011 ; Vol. 35, No. 2. pp. 82-88.
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abstract = "to evaluate the association between phenotype and sun sensitivity factors, sun protection behavior, ethnicity and the area of residence in school-aged children. a cross-sectional study in the framework of a survey of children using a self-administered questionnaire to be filled in by parents. 56390 children attending primary schools located in the Italian provinces of Brindisi, Rome, Forl{\`i} and Genova, in the period between 1998-2002. Odds Ratios (ORs) and their relative 95{\%} Confidence Intervals (95{\%} CI) are to be computed through univariate and multivariate logistic regression models. {"}FOTO positive{"} phenotype, a proxy variable of the fair phenotype, was directly and significantly associated with the tendency to sunburn (OR 4.75; 95{\%} CI 4.54-4.96), the use of sunscreens (OR 1.79; 95{\%} CI 1.63-1.97), the number of grandparents born in the northern areas (OR 1.63; 95{\%} CI 1.45-1.83, for four northern grandparents versus none), the presence of freckles on the face (OR 1.62; 95{\%} CI 1.53-1.72) and of naevi on the left forearm (OR 1.20; 95{\%} CI 1.15-1.26). A positive association was also found for the residence in the northern areas using the area of Brindisi as the reference category, (Rome: OR 1.02; 95{\%} CI 0.95-1.10; Forl{\`i}: OR 1.05; 95{\%} CI 0.96-1.15; Genova: OR 1.16; 95{\%} CI 1.08-1.26); the ORs increase with latitude, as does the incidence rate of melanoma in Italy. An inverse association was observed with the male sex (OR 0.92; 95{\%} CI 0.88-0.96), the increase of school-class level (OR 0.65; 95{\%} CI 0.60-0.69, for the highest versus the lowest school-class level) and the ability to tan (OR 0.40; 95{\%} CI 0.36-0.43). these findings confirmed that the fairness phenotype is associated with other skin cancer risk factors in children and pointed out that the high-risk phenotype has a geographical distribution consistent with the pattern of melanoma incidence in the Italian areas covered by the study.",
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AU - Falcini, Fabio

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