Skin immunity and its dysregulation in psoriasis

Caterina Lanna, Mara Mancini, Roberta Gaziano, Maria Vittoria Cannizzaro, Marco Galluzzo, Marina Talamonti, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Ying Wang, Yufang Shi, Elena Campione, Luca Bianchi

Research output: Contribution to journalReview articlepeer-review

Abstract

The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibrium of well-regulated relations between different cells and exogenous pathogens. Inflammatory skin diseases are directly linked to the dysregulation of this equilibrium. The present review discusses the role of the immune system, of T cells, in the etiopathogenesis of psoriasis, illustrating a potential rationale for innovative therapeutic intervention.

Original languageEnglish
Pages (from-to)2581-2589
Number of pages9
JournalCell Cycle
Volume18
Issue number20
DOIs
Publication statusPublished - Oct 18 2019

Keywords

  • biologic therapies
  • cytokines
  • immunity
  • lymphocytes
  • Psoriasis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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