Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives

Giovanni Genovese, Chiara Moltrasio, Emilio Berti, Angelo Valerio Marzano

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the "severe acute respiratory syndrome coronavirus 2"(SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, dyspnea and hypogeusia/hyposmia. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasingly reported in the last few months. Summary: The polymorphic nature of COVID-19-associated cutaneous manifestations led our group to propose a classification, which distinguishes the following six main clinical patterns: (i) urticarial rash, (ii) confluent erythematous/maculopapular/morbilliform rash, (iii) papulovesicular exanthem, (iv) chilblain-like acral pattern, (v) livedo reticularis/racemosa-like pattern, (vi) purpuric "vasculitic"pattern. This review summarizes the current knowledge on COVID-19-associated cutaneous manifestations, focusing on clinical features and therapeutic management of each category and attempting to give an overview of the hypothesized pathophysiological mechanisms of these conditions.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalDermatology
Volume237
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • COVID-19
  • Cutaneous manifestations
  • SARS-CoV-2

ASJC Scopus subject areas

  • Dermatology

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