Skin structural modifications induced by mechanical stress

Daniele Innocenzi, Giuseppe La Torre, Chiara Panetta, Maria Rita Nasca, Giuseppe Micali, Stefano Calvieri

Research output: Contribution to journalArticlepeer-review


The effects of mechanical forces have been extensively studied in different biological compartments. As regards the skin, it is constantly exposed to stretching and bending in physiologic as well as in pathologic conditions. However, little is known about the effect of mechanical forces on dermal fibroblasts. In order to investigate this issue, we evaluated the cutaneous histopathological features of 15 patients treated by mechanical forces with a new noninvasive, suction-assisted massage technique, in attempt to demonstrate morphological modifications of epidermis and dermis compared with non-treated skin. We quantified these alterations by image analysis, showing significant differences between stressed skin and unstressed controls. The most important changes were observed on fibroblasts and skin vessels.

Original languageEnglish
Pages (from-to)91-105
Number of pages15
JournalJournal of Medicine
Issue number1-6
Publication statusPublished - 2005


  • Fibroblasts
  • Image analysis
  • Mechanical forces
  • Vessels

ASJC Scopus subject areas

  • Medicine(all)


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