Skin surface lipids in HIV sero-positive and HIV sero-negative patients affected with seborrheic dermatitis

S. Passi, M. Picardo, A. Morrone, C. De Luca, F. Ippolito

Research output: Contribution to journalArticlepeer-review

Abstract

Skin surface lipids of patients affected with seborrheic dermatitis both HIV sero-negative (C group) and HIV sero-positive (B group) have been studied by capillary Gas chromatography-Mass spectrometry (GC-MS) in comparison with normal age matched controls (A group) to determine whether, among the three groups of individuals, there were qualitative and quantitative changes in lipid class composition and in the fatty acid and alcohol components of lipid fractions. With regard to percent composition of skin surface lipid fractions, no significant differences were found between HIV sero-positive and HIV sero-negative patients with seborrheic dermatitis. The observed significant reduction of total lipids (μg/sq cm) in the sites affected with the disease in comparison with controls was associated with a slight but significant decrease of squalene (P <0.05) and with a corresponding increase of cholesterol and cholesterol esters (P <0.05). These abnormalities in lipid fractions and total lipids were not observed in the uninvolved skin of subjects with seborrheic dermatitis. Fatty acid and alcohol patterns of skin lipid fractions were not significantly different among the three groups of individuals.

Original languageEnglish
Pages (from-to)84-91
Number of pages8
JournalJournal of Dermatological Science
Volume2
Issue number2
DOIs
Publication statusPublished - 1991

Keywords

  • AIDS
  • Seborrheic dermatitis
  • Skin surface lipids

ASJC Scopus subject areas

  • Dermatology

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