Skin sympathetic adrenergic innervation: An immunofluorescence confocal study

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of this study was to characterize sympathetic adrenergic innervation of the skin in healthy subjects using dopamine β hydroxylase (DβH) as a specific marker for noradrenergic fibers. Methods: Sympathetic adrenergic innervation of human skin was studied in 10 healthy subjects by indirect immunofluorescence and confocal microscopy applied to punch skin biopsies. Noradrenergic fibers were identified both in glabrous and hairy skin using DβH antibody. Results: DβH immunoreactive fibers were mainly localized in arteriovenous anastomoses, arrector pilorum muscles, and arterioles, whereas few adrenergic fibers were found around sweat glands. Interpretation: Our description of sympathetic adrenergic innervation of human skin aims to improve the diagnostic ability of skin biopsy to detect selective autonomic nervous system disorders.

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalAnnals of Neurology
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2006

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Skin sympathetic adrenergic innervation: An immunofluorescence confocal study'. Together they form a unique fingerprint.

Cite this