Skin test protocols in immediate reactions to β-lactams

Maria José Torres, Miguel Blanca, Javier Fernández, Antonio Romano

Research output: Contribution to journalArticlepeer-review


Diagnosis of immediate allergic reactions to betalactams is a problem seen in everyday clinical practice that is becoming more complex due to the wide variety of betalactams available. Diagnosis is usually based upon clinical history plus skin testing. In vitro testing can be necessary and controlled administration, often called by some controlled challenge, can be necessary for completing the evaluation of the patient. Because the clinical history is not always reliable and many people claimed to be allergic in fact tolerate the drug, and because of reduction in sensitivity of skin tests and of in vitro methods, an increasing number of patients require drug tolerance tests for diagnosis, with the corresponding risk. Evidence indicates that many people are falsely labeled as allergic to β-lactams and often an adequate therapy is denied to them. It is, therefore, necessary to standardize skin test protocols and to develop new in vitro techniques to achieve reliable, risk-free diagnoses.

Original languageEnglish
Pages (from-to)216-219
Number of pages4
JournalAllergy and Clinical Immunology International
Issue number5
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Immunology and Allergy


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