Skin ultrastructure after calcipotriol treatment: A transmission electron microscopic and freeze-fracture study on psoriatic patients

Stefano Cavicchini, Andrea Brezzi, Giovanni Gasparini, Ruggero Caputo

Research output: Contribution to journalArticle

Abstract

Electron microscopic details in psoriatic skin during calcipotriol application are reported. Ten psoriatic patients (PASI score 3-14) were punch-biopsied on typical lesions before treatment and 2, 4 and 8 weeks after it. Two patients dropped out after 1 month because of lack of clinical response. Skin blocks were processed routinely for transmission electron microscopy and freeze-fracture techniques. The first modifications were the disappearance of fine intercellular granular material and the restoration of the granular layer. After 4 weeks desmosomes appeared in greater amounts than at baseline. Horny layer lipid vacuoles and remnants of nuclei as well as multilayering of the basal lamina were only locally observed. Dilatation of dermal capillaries was still seen even after 8 weeks. Freeze-fracture confirmed the data about the desmosomes and revealed a marked decrease of the gap junctions. Calcipotriol basically seems to act similarly to other antipsoriatic agents, though faster. The persistence of microvasculature dilatation could imply the need for long-term therapy.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalActa Dermato-Venereologica
Volume76
Issue number3
Publication statusPublished - 1996

Keywords

  • dilatation of dermal capillaries
  • fine intercellular granular material
  • multilayering of basal lamina

ASJC Scopus subject areas

  • Dermatology

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