Skin wound healing process and new emerging technologies for skin wound care and regeneration

Erika Maria Tottoli, Rossella Dorati, Ida Genta, Enrica Chiesa, Silvia Pisani, Bice Conti

Research output: Contribution to journalReview articlepeer-review


Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design.

Original languageEnglish
Article number735
Pages (from-to)1-30
Number of pages30
Issue number8
Publication statusPublished - Aug 2020


  • 3D bioprinting
  • Chronic wounds
  • Drug delivery
  • Electrospinning
  • Wound
  • Wound healing

ASJC Scopus subject areas

  • Pharmaceutical Science


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