Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature

Alessandro Rizzo, Maria Concetta Nigro, Vania Ramponi, Carmine Gallo, Anna Myriam Perrone, Pierandrea De Iaco, Giovanni Frezza, Damiano Balestrini, Maika Di Benedetto, Jarno Morbiducci, Maria Abbondanza Pantaleo, Margherita Nannini

Research output: Contribution to journalArticlepeer-review


Uterine leiomyosarcoma (uLMS) is a rare and aggressive malignancy with poor clinical outcomes. Even when localized, uLMS is associated with high rates of local and distant recurrences that are usually fatal. Common sites of recurrence are lung, liver, pelvic lymph nodes, and vertebral and long bones, though atypical patterns of recurrence have been described. Among them, intracranial recurrence appears as a rare finding, almost exceptional in skull and dura. We describe the case of a solitary skull metastasis from uLMS in a 39-year-old woman, which represents the third reported case of skull recurrence in literature. After multidisciplinary discussion, the patient underwent surgery and received adjuvant radiotherapy. After 4 months, she is currently alive, without evidence of extracranial disease. This case highlights the importance of suspecting and recognizing atypical and extremely rare metastasis to this region. We encourage the need for large case series in order to provide further information about cranial recurrences of uLMS taking into account the paucity of data currently available in literature and the frequently unpredictable behavior of this rare and highly lethal disease.

Original languageEnglish
Article number869
JournalFrontiers in Oncology
Publication statusPublished - Jun 16 2020
Externally publishedYes


  • intracranial recurrence
  • skull metastasis
  • uterine cancer
  • uterine leiomyosarcoma
  • uterine sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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